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Whole-body counter measurements of residents of Fukushima Prefecture have been extensively performed after the Fukushima Dai-ichi Nuclear Power Plant accident in March 2011. These measurements have demonstrated that the levels of internal contamination with radioactive cesium (Cs and Cs) in the residents are very low. This article provides an overview of and lessons learned from these whole-body counter measurements with emphasis on the technical problems encountered, and it discusses the effective use of whole-body counters for assessing the internal thyroid doses of individuals when direct measurements of I in the thyroid are difficult or impossible to implement for the total affected population in a short time after a nuclear reactor accident. The application of this dose reconstruction method requires determining the intake ratio of I to cesium isotopes at appropriate times and considers the short biological half-lives of cesium isotopes, in particular for children.
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http://dx.doi.org/10.1097/HP.0000000000000862 | DOI Listing |
Nucl Med Biol
August 2025
PET Imaging Center, University Hospital North Norway, Hansine Hansens veg 82, 9019 Tromsø, Norway; Department of Medical Biology, Tumor Biology Research Group, UiT The Arctic University of Norway, Hansine Hansens veg 18, 9019 Tromsø, Norway. Electronic address:
Unlabelled: Targeted radionuclide therapy (TRT) is an emerging pillar of precision medicine, with prostate-specific membrane antigen (PSMA)-targeted agents like [Lu]PSMA-617 demonstrating notable clinical success. Achieving optimal therapeutic efficacy while minimizing toxicity requires precise tumor and organ dosimetry based on accurate time-activity curves (TACs) derived from molecular imaging. Glioblastoma (GBM), a highly treatment-resistant brain tumor with limited therapeutic possibilities, has shown PSMA expression, opening new avenues for TRT.
View Article and Find Full Text PDFStem Cell Res Ther
July 2025
Department of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, Columbia, SC, 29208, USA.
Background: G-protein coupled receptor 68 (Gpr68) was enriched in long-term hematopoietic stem cells, indicating a potential role of Gpr68 in the HSC function. However, there is no significant phenotype in the HSC biology of Gpr68 whole-body KO mice, which may be counteracted by compensation. To study an intrinsic function of Gpr68 in hematopoiesis, Gpr68;Vav-cre mouse model where the Gpr68 gene was specifically deleted in hematopoietic cells was generated and monitored here (C57BL/6 J genetic background).
View Article and Find Full Text PDFJ Nucl Med
September 2025
Molecular Imaging Program at Stanford, Department of Radiology, Stanford University School of Medicine, Stanford, California;
The variable response to cancer immunotherapies highlights a critical gap in our ability to predict and monitor treatment efficacy. To address this, there is an urgent clinical need for advanced molecular imaging technologies that can noninvasively and precisely assess whole-body immune responses. The OX40 receptor (CD134), a potent costimulatory molecule on T cells, serves as a highly specific marker of T-cell activation, an early and crucial event in immunotherapy efficacy.
View Article and Find Full Text PDFRationale And Objectives: Dual-source photon-counting CT (DS-PCCT) facilitates an unprecedented combination of spectral information and ultra-high resolution in whole-body imaging of multiple myeloma. This study explored the distinct characteristics of soft tissue, fat, and calcium in virtual monoenergetic images (VMI) with low photon energy, aiming to identify criteria of lesion vitality.
Materials And Methods: This retrospective study included 51 patients with multiple myeloma (67.
Health Phys
August 2025
Human Monitoring Laboratory, Radiation Protection Bureau, 775 Brookfield Road, Ottawa, Ontario K1A 1C1, Canada.
The Human Monitoring Laboratory (HML) at Health Canada collaborated with a nuclear industry facility to help characterize a contamination event with a male worker who showed contamination after a routine whole body count. Monte Carlo simulation was used to model the whole body counter (WBC) using an appropriately matched male voxel phantom. Ratios of the resulting modeled detector counting efficiencies were used to help determine the most likely area of contamination in or on the worker, thereby helping to approximate the potential dose received by the worker.
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