Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

An approach for the design of functionalized cyclic peptides is established for use in 3D cell culture and in cell targeting. Sequential orthogonal click reactions, specifically a photoinitiated thiol-ene and strain promoted azide-alkyne cycloaddition, were utilized for peptide cyclization and conjugation relevant for biomaterial and biomedical applications, respectively.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433322PMC
http://dx.doi.org/10.1039/c8cc03218aDOI Listing

Publication Analysis

Top Keywords

design functionalized
8
functionalized cyclic
8
cyclic peptides
8
orthogonal click
8
click reactions
8
cell culture
8
peptides orthogonal
4
reactions cell
4
culture targeting
4
targeting applications
4

Similar Publications

Treating neurological disorders is challenging due to the blood-brain barrier (BBB), which limits therapeutic agents, including proteins and peptides, from entering the central nervous system. Despite their potential, the BBB's selective permeability is a significant obstacle. This review explores recent advancements in protein therapeutics for BBB-targeted delivery and highlights computational tools.

View Article and Find Full Text PDF

This study presents a novel variable gain intermittent boundary control (VGIBC) approach for stabilizing delayed stochastic reaction-diffusion Cohen-Grossberg neural networks (SRDCGNN). In contrast to traditional constant gain intermittent boundary control (CGIBC) methods, the proposed VGIBC framework dynamically adjusts the control gain based on the operational duration within each control cycle, thereby improving adaptability to variations in work interval lengths. The time-varying control gain is designed using a piecewise interpolation method across work intervals, defined by a finite set of static gain matrices.

View Article and Find Full Text PDF

Region-guided attack on the segment anything model.

Neural Netw

September 2025

School of Electronic Science and Engineering, Nanjing University, China. Electronic address:

The Segment Anything Model (SAM) is a cornerstone of image segmentation, demonstrating exceptional performance across various applications, particularly in autonomous driving and medical imaging, where precise segmentation is crucial. However, SAM is vulnerable to adversarial attacks that can significantly impair its functionality through minor input perturbations. Traditional techniques, such as FGSM and PGD, are often ineffective in segmentation tasks due to their reliance on global perturbations that overlook spatial nuances.

View Article and Find Full Text PDF

Computational modeling for PPE filtration: Informed by material characterization, microbial penetration, and particle mechanics.

J Occup Environ Hyg

September 2025

Division of Biology, Chemistry, and Materials Science, Office of Science and Engineering Laboratories, US Food and Drug Administration (FDA), Oak Ridge, Tennessee.

This work assesses the current characterization framework of single-use personal protective equipment (PPE) per recognized consensus standards and presents a novel quantitative approach to refining characterization of barrier materials and predicting PPE performance. Scanning electron microscopy (SEM) and image analysis software (Diameter J) were used to examine the microscopic fiber and pore structure of filter layers of surgical N95 filtering facepiece respirators, before and after exposure to chemicals used in decontamination modalities (vaporized hydrogen peroxide or ozone). The effect of porosity on penetration was assessed by bacterial filtration efficiency (BFE) testing.

View Article and Find Full Text PDF

Per- and polyfluoroalkyl substances (PFASs) are environmentally persistent, bioaccumulative, and toxic chemicals that contaminate global drinking water resources. Their ubiquity and potential impact on human health motivate large-scale remediation. Conventional materials used to remove PFASs during drinking water production are functionally inefficient or energetically expensive, motivating the discovery of new materials and technologies.

View Article and Find Full Text PDF