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http://dx.doi.org/10.1111/head.13267 | DOI Listing |
Int J Environ Health Res
September 2025
Department of Epidemiology, School of Public Health, Shanxi Medical University, Jinzhong, China.
The mechanism underlying the effects of Polycyclic aromatic hydrocarbons (PAHs) on missed abortion (MA) remains unclear. This study explored the relationship between PAHs exposure, telomere length (TL), metabolizing enzyme gene polymorphism, and MA in a case-control study with 253 pregnant women. A competitive enzyme-linked immunosorbent assay (ELISA) was used to quantify PAH-DNA adducts.
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
August 2025
Institute of Statistics, National University of Kaohsiung, 811 Kaohsiung, Taiwan.
Background: Obesity is a chronic condition linked to health issues such as diabetes, heart disease, and increased cancer risk. High body mass index (BMI) is associated with cancers such as breast and colorectal cancer due to hormone imbalances and inflammation from excess fat, whereas a low BMI can raise cancer risk by weakening the immune system. Maintaining a normal BMI improves cancer treatment outcomes, but in some cases, higher BMI might offer protective effects-a phenomenon known as the "obesity paradox".
View Article and Find Full Text PDFPLoS Comput Biol
September 2025
School of Computer Software, College of Intelligence and Computing, Tianjin University, Tianjin, China.
Drug-induced liver injury is a leading cause of high attrition rates for both candidate drugs and marketed medications. Previous in silico models may not effectively utilize biological drug property information and often lack robust model validation. In this study, we developed a graph convolutional network embedded with a biological graph learning (BioGL) module-named BioGL-GCN(Biological Graph Learning-Graph Convolutional Network)-for drug-induced liver injury prediction using toxicogenomic profiles.
View Article and Find Full Text PDFCancer Causes Control
September 2025
Orthopedics department, Guangdong Provincial Hospital of Chinese Medicine (The Second Affiliated Hospital of Guangzhou University of Chinese Medicine), Guangzhou, China.
Background: Bone metastasis (BM) in breast cancer affects patient prognosis, but its molecular mechanisms and relationship with the gut microbiome are not well understood. This study aims to explore gene expression and gut microbiome differences between BM and non-bone metastasis (BNM) patients, which could shed light on cancer progression and metastasis.
Methods: We utilized a multi-omics approach, integrating transcriptomic and microbiomic data.
Toxicol Ind Health
September 2025
Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Biruni University, İstanbul, Türkiye.
Neonicotinoid insecticides and triazole fungicides are widely used in agriculture, often in combination with other pesticides, leading to concerns about potential health effects. This study investigated the combined effect of these chemicals using the Comparative Toxicogenomics Database (CTD) to identify common target genes, followed by functional enrichment analysis and gene-gene and protein-protein interaction assessments. In this study, it was determined that pesticides may interfere with biological processes such as steroid hydroxylase activity, oxidoreductase activity, and steroid metabolism, and cause hormonal imbalances and endocrine system disorders.
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