Intravascular Ultrasound Studies of Plaque Progression and Regression: Impact of Lipid-Modifying Therapies.

Cardiol Clin

South Australian Health and Medical Research Institute, University of Adelaide, PO Box 11060, Adelaide, SA 5001, Australia. Electronic address:

Published: May 2018


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Application of serial intravascular ultrasound imaging within the coronary arteries enables characterization of the factors associated with progression of atherosclerotic plaque. Integration into clinical trials has enabled determination of the impact of medical therapies on coronary disease. These trials have provided important insights into the effects of lipid-modifying agents currently used in clinical practice and of experimental agents at early stages of clinical development. The results of these trials are reviewed.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccl.2017.12.014DOI Listing

Publication Analysis

Top Keywords

intravascular ultrasound
8
ultrasound studies
4
studies plaque
4
plaque progression
4
progression regression
4
regression impact
4
impact lipid-modifying
4
lipid-modifying therapies
4
therapies application
4
application serial
4

Similar Publications

Prospective Evaluation of Thrombotic Complications After Internal Jugular Vein Cannulation for External Bypass.

J Cardiothorac Vasc Anesth

August 2025

Goethe-University Frankfurt, University Hospital Frankfurt, Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Frankfurt, Germany; Department of Anesthesiology and Intensive Care Medicine, Rheinische Friedrich-Wilhelms-University, University Hospital Bonn, Bonn, Germany.

Objectives: To determine the incidence and subsequent complications of internal jugular vein (IJV) thrombosis after cannulation performed during cardiopulmonary bypass (CPB) to ensure adequate venous drainage during minimally invasive cardiac surgery.

Design: Single-center observational trial SETTINGS: Intensive care postoperative monitoring of cardiac surgery patients and diagnosis of IJV thrombi at a university tertiary hospital during the 13-month study period from December 1, 2022, to January 11, 2024.

Participants: 44 patients undergoing catheterization of the IJV for total CPB.

View Article and Find Full Text PDF

Sonographic examination of major vessels can be a valuable bedside tool for perioperative hemodynamic assessment. In the present review, we present the anatomic and physiological aspects of internal jugular vein ultrasonography, its utility in assessing central venous pressure, intravascular volume status, fluid responsiveness, and its predictive value regarding post-spinal anesthesia hypotension. The existing literature is primarily comprised of small, observational studies with great heterogeneity in their methodology and shortcomings in data development and analysis, rendering the generalization of their results difficult to interpret for daily clinical practice.

View Article and Find Full Text PDF

Background: An inward force is experienced by the guide catheter during device retrieval resulting in potential risk of deep engagement into the ostio-proximal coronary segment. This undesired movement can result in coronary injury. There is no systematic data or reports of techniques to prevent such inadvertent guide movement during difficult retrieval of devices.

View Article and Find Full Text PDF

Background: Cardiac issues following radiotherapy are increasingly prevalent among patients with thoracic cancer and coronary disease. However, the mechanisms underlying radiotherapy-induced plaque instability and changes in plaque characteristics on imaging remain unclear. This study used single-cell RNA sequencing to identify key features of vulnerable plaques following radiotherapy.

View Article and Find Full Text PDF

A 33-year-old male developed pulmonary vein (PV) stenosis 3 months after PV isolation for atrial fibrillation. Stents were implanted in the left superior and inferior PVs, but 2 years later, in-stent restenosis occurred. Intravascular ultrasound and nonobstructive general angioscopy (NOGA) revealed severe ostial stenosis and neointimal hyperplasia.

View Article and Find Full Text PDF