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Thyroid storm is the life-threatening end-organ manifestation of severe thyrotoxicosis. If left untreated, thyroid storm may cause acute heart failure, multiorgan dysfunction, and death. A high degree of suspicion is necessary to make the diagnosis and start antithyroid medications to decrease mortality. Thyroid storm is generally seen in patients with Graves' disease but should also be suspected in patients with fever, tachycardia, altered mental status, and risk factors including local trauma to the neck, such as strangulation. Based on our review, we report the first case of thyroid storm after strangulation as the presentation of previously undiagnosed Graves' disease.
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http://dx.doi.org/10.1155/2018/4190629 | DOI Listing |
Front Med (Lausanne)
August 2025
Department of Endocrinology, Chengdu Shuangliu Hospital of Traditional Chinese Medicine, Chengdu, China.
Objectives: The association between SARS-CoV-2 infection and endocrine emergencies (such as fulminant type 1 diabetes mellitus and subacute thyroiditis) has received increasing attention. However, concurrent manifestations of these two conditions within a short period of time after infection are exceedingly rare, and the underlying mechanisms and clinical management strategies remain unclear.
Case Presentation: A 45-year-old Chinese man developed sudden polydipsia, polyuria, and cervical pain on day 7, within 2 weeks of SARS-CoV-2 infection.
JCEM Case Rep
October 2025
Servicio de Endocrinología y Nutrición, Hospital Universitario Clínico San Carlos, Madrid 28040, Spain.
This case report describes a 25-year-old woman with type 1 diabetes mellitus (T1DM) and autoimmune thyroid disease (AITD) who developed Addison disease (AD). The diagnosis was suspected due to a significant decrease in insulin requirement and recurrent hypoglycemia despite adjustments in insulin pump therapy. The patient exhibited typical clinical features of AD, including hyperpigmentation and electrolyte imbalances.
View Article and Find Full Text PDFJCEM Case Rep
October 2025
Henry Ford Providence Southfield Internal Medicine, Southfield, MI 48075, USA.
We report a 28-year-old woman with refractory hypoglycemia, hypotension, and profound fatigue found to have panhypopituitarism secondary to Sheehan syndrome. Although she had a remote history of postpartum hemorrhage marked by agalactia and secondary amenorrhea, her diagnosis was delayed until she developed an adrenal crisis in the setting of acute pyelonephritis. Comprehensive endocrine testing confirmed secondary adrenal insufficiency, central hypothyroidism, hypogonadotropic hypogonadism, and lactotroph failure; Magnetic resonance imaging demonstrated a partially empty sella consistent with remote pituitary infarction.
View Article and Find Full Text PDFCase Rep Oncol
January 2025
Division of Endocrine and Thyroid Surgery, Department of Surgery, National University Hospital, Singapore, Singapore.
Introduction: Sympathetic paragangliomas (PGLs) are rare neuroendocrine tumours originating from chromaffin cells, primarily in the thorax, abdomen, and pelvis. Paediatric PGLs are particularly uncommon, but they represent a notable cause of secondary hypertension in children. These tumours frequently have a genetic basis, with up to 40% of patients carrying germline mutations, including variants of unknown significance (VUS), which present diagnostic and management challenges.
View Article and Find Full Text PDFCureus
July 2025
Department of Oral Surgery, Sapporo Medical University School of Medicine, Sapporo, JPN.
Thyroid storm is a life-threatening condition in which patients with untreated or poorly controlled thyroid disease experience excessive thyroid hormone action triggered by severe stress, resulting in multiple organ dysfunction. We present a case of suspected thyroid storm during surgery for a left mandibular fracture under general anesthesia. The patient was a 23-year-old male, and a preoperative interview revealed no notable medical history.
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