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This case report describes a 25-year-old woman with type 1 diabetes mellitus (T1DM) and autoimmune thyroid disease (AITD) who developed Addison disease (AD). The diagnosis was suspected due to a significant decrease in insulin requirement and recurrent hypoglycemia despite adjustments in insulin pump therapy. The patient exhibited typical clinical features of AD, including hyperpigmentation and electrolyte imbalances. Early recognition and prompt treatment are crucial in preventing a life-threatening adrenal crisis. This case highlights the importance of vigilant monitoring of T1DM patients, especially those with other autoimmune diseases, for early signs of AD. The use of continuous glucose monitoring (CGM) and insulin pump therapy can aid in the management and early detection of this complication.
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http://dx.doi.org/10.1210/jcemcr/luaf181 | DOI Listing |
Zhonghua Nei Ke Za Zhi
September 2025
Department of Endocrinology, the First Medical Center of Chinese PLA General Hospital, Beijing 100039, China.
Clinical data of two patients with X-linked adrenoleukodystrophy (X-ALD) initially presenting as Addison's disease were collected from the Department of Endocrinology, First Medical Center of Chinese PLA General Hospital. Relevant medical history, clinical features, laboratory tests, and genetic results were analyzed. The two male patients, aged 7 years (case 1) and 15 years (case 2), initially presented with generalized skin hyperpigmentation, without any family history of similar disorders.
View Article and Find Full Text PDFJCEM Case Rep
October 2025
Servicio de Endocrinología y Nutrición, Hospital Universitario Clínico San Carlos, Madrid 28040, Spain.
This case report describes a 25-year-old woman with type 1 diabetes mellitus (T1DM) and autoimmune thyroid disease (AITD) who developed Addison disease (AD). The diagnosis was suspected due to a significant decrease in insulin requirement and recurrent hypoglycemia despite adjustments in insulin pump therapy. The patient exhibited typical clinical features of AD, including hyperpigmentation and electrolyte imbalances.
View Article and Find Full Text PDFWorld J Gastroenterol
August 2025
Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK 74017, United States.
Background: Hepatocellular carcinoma (HCC) is a global health concern, representing the second most common cause of malignancy-related mortality in the world. The primary cause of HCC in the United States is chronic infection with the hepatitis C virus (HCV). Clinical observations have established sex-based differences in HCV infection with the disease progressing more severely and more rapidly in males and postmenopausal females compared to premenopausal females, suggesting that estrogens and their receptors may play an important role in hepatic defenses and development of HCV-mediated HCC.
View Article and Find Full Text PDFRev Peru Med Exp Salud Publica
August 2025
Facultad de Medicina, Universidad Nacional de Trujillo, Trujillo, Perú.
Systemic mycoses, such as cryptococcosis, mainly affect the lungs and central nervous system; however, involvement of other organs, such as the adrenal glands, is rare. This has been described in some cases of primary adrenal insufficiency (PAI) of fungal origin, which are associated with high mortality. We present the case of a 65-year-old immunocompetent man who presented clinical manifestations of adrenal insufficiency.
View Article and Find Full Text PDFClin Endocrinol (Oxf)
September 2025
Department of Molecular Medicine and Surgery, Karolinska Institutet and Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden.
Objective: Standard glucocorticoid (GC) replacement therapy in autoimmune Addison's disease (AAD) fails to replicate natural cortisol rhythms. Despite adherence, patients report persistent fatigue, reduced vitality, and impaired wellbeing, ultimately lowering health-related quality of life (HRQoL). Cortisol is essential for sleep regulation, yet the impact of cortisol imbalance on sleep and HRQoL in AAD remains poorly understood.
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