Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Changes in protein glycosylation have been reported in various types of cancer, including cholangiocarcinoma (CCA). Nanospray ionization-linear ion trap mass spectrometry (NSI-MS ) was used in the present study to determine the comparative structural glycomics of the -linked glycans in the serum of patients with CCA compared with healthy controls. A total of 5 high-mannose and 4 complex -linked glycans were detected. Mannose-N-acetyl-glucosamine was the most abundant structure among the high-mannose types (control 12.12±2.54 vs. CCA 9.27±2.66%), whereas NeuAc2H2N2M3N2 predominated the complex types (control 61.17±2.55 vs. CCA 64.68±4.23%). The expression of 3 different -glycans differed significantly between the CCA cases and controls. These included mannose-N-acetyl-glucosamine (P=0.044), mannose-N-acetyl-glucosamine (Ρ=0.030) and NeuAc3H3N3M3N2F (Ρ=0.002). These three glycan structures may therefore be associated with tumor progression in CCA and may be useful for its diagnosis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772869 | PMC |
| http://dx.doi.org/10.3892/ol.2017.7384 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Knockdown of ARHGDIB promotes autophagy and reduces inflammation in LPS-induced alveolar epithelial cells via the PRKACB/NF-κB pathway.
Allergol Immunopathol (Madr)
September 2025
Department of Respiratory and Critical Care Medicine, the Wenzhou Central Hospital and Dingli Clinical Institute of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Background: Acute lung injury (ALI) is a critical clinical condition with high mortality, necessitating the development of more effective therapeutic strategies. Rho Guanine nucleotide dissociation inhibitor (GDP) beta (ARHGDIB) has been shown to exert protective effects against noxious stimuli in various disease models.
Objective: In this study, we investigated whether ARHGDIB knockdown had a protective effect on lipopolysaccharide (LPS)-induced injury in alveolar epithelial cells and elucidated its underlying molecular mechanisms.
[Application of chitosan hydrochloride coated fine and fragile tissues for electron microscopy sample preparation].
Zhonghua Bing Li Xue Za Zhi
September 2025
Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.
Amelioration of ovalbumin-induced allergic rhinitis in rats by ginseng residue oligosaccharides and ginseng polysaccharides via multi-omics analysis.
Int J Biol Macromol
September 2025
College of Food Science and Engineering, Jilin Agricultural University, Changchun, 130118, China. Electronic address:
This research explored the effects of ginseng residue oligosaccharides (GRO-N) and ginseng polysaccharides (GP-N) on alleviating allergic rhinitis (AR). In a rat model induced by ovalbumin (OVA), both high doses of GRO-N (GRO-N-H) and GP-N (GP-N-H) significantly decreased the frequency of sneezing and rubbing behaviors in AR-affected rats. Histopathological evaluations and cytokine analyses revealed that GRO-N-H and GP-N-H notably lowered the count of goblet cells and reduced inflammatory cytokine levels in these rats.
View Article and Find Full Text PDFInflammatory-Driven Vitamin A Transport Dysfunction in Ulcerative Colitis.
Int J Vitam Nutr Res
September 2025
Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, 300070 Tianjin, China.
Background: Retinol-binding protein 4 (RBP4) is a vitamin A transport protein synthesized in the liver and also plays a crucial role in inflammation and immune regulation. Low serum vitamin A levels have been observed in both pediatric and adult patients with ulcerative colitis (UC). The association between serum vitamin A levels and serum RBP4 levels, as well as the underlying mechanism involved inimpaired vitamin A transport during inflammation in UC patients, has yet to been investigated.
View Article and Find Full Text PDFSparc Suppresses Microglial Neuroinflammation and Promotes Axonal Regeneration by Interacting With Uba52.
Front Biosci (Landmark Ed)
August 2025
Department of Spine Surgery, Zhongda Hospital Southeast University, 210009 Nanjing, Jiangsu, China.
Background: After spinal cord injury (SCI), pro-inflammatory microglia accumulate and impede axonal regeneration. We explored whether secreted protein acidic and rich in cysteine (Sparc) restrains microglial inflammation and fosters neurite outgrowth.
Methods: Mouse microglial BV2 cells were polarized to a pro-inflammatory phenotype with lipopolysaccharides (LPSs).