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http://dx.doi.org/10.20452/pamw.4184 | DOI Listing |
Cancers (Basel)
August 2025
Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Paraneoplastic syndromes (PNSs) are pathologic conditions produced by neoplasms not attributable to tumor invasion or metastasis. The clinical manifestations of PNSs can precede the diagnosis; these symptoms may serve as early indicators of underlying malignancy. Standard imaging modalities, such as computed tomography (CT) and magnetic resonance imaging (MRI), have limited sensitivity in detecting small or early-stage PNS-associated tumors.
View Article and Find Full Text PDFPharmgenomics Pers Med
August 2025
Department of Oncology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang, 441000, People's Republic of China.
Background: KRAS mutations are typically mutually exclusive in non-small cell lung cancer (NSCLC), with the G12C mutation being the most common subtype. The coexistence of KRAS and EGFR mutations is exceedingly rare and is typically emerges as a secondary event following acquired resistance to EGFR-targeted therapies. We presented a case of a newly diagnosed NSCLC patient harboring concurrent EGFR L858R and KRAS G12A mutations.
View Article and Find Full Text PDFAnn Nucl Med
August 2025
Department of Ophthalmology, Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital Northwest University, Xi'an, 710004, China.
Objective: To evaluate the diagnostic performance of F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) in detecting metastatic conjunctival melanoma (CM).
Methods: This retrospective study enrolled 67 patients with histopathologically confirmed CM who underwent F-FDG PET/CT for follow-up or suspected recurrence. Parameters including short-axis diameter of lesions, maximum standardized uptake value (SUVmax), the target-to-nontarget (T/NT) ratios of cervical lymph nodes, and bone lesion characterization (osteolytic, osteoblastic, or unchanged) were evaluated.
Biomater Res
August 2025
School of Pharmaceutical Science, Nanjing Tech University, Nanjing 211816, China.
The management of medulloblastoma (MB) remains a significant challenge, primarily attributed to the presence of cancer stem cells and the inadequate delivery of therapeutic agents across the blood-brain barrier. GLI, as a regulator of the hedgehog signaling pathway in normal cerebellum development, also exerts pivotal functions in MB initiation, progression, and metastasis and maintains the stemness of MB stem cells. In this study, we devised a combined therapeutic approach by integrating the BRD4 inhibitor JQ1 with the SMO inhibitor saikosaponin B1 (SSB1) to inhibit MB via regulation of GLI activation.
View Article and Find Full Text PDFInt J Surg Case Rep
September 2025
Faculty of Medicine and Pharmacy, Mohammed Ist University, Oujda, Morocco; Department of oncological Surgery, Regional oncology Center, Mohammed VI University Hospital Oujda, Morocco.
Introduction And Importance: Meningiomas are the most common primary intracranial tumors and are typically benign. However, high-grade variants are rare and have a greater risk of recurrence and distant metastasis. Recognizing these exceptional metastatic presentations is essential for accurate diagnosis and management.
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