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Background: Autologous fat injection is getting popular in cosmetic procedures, however, still has a risk of fat embolism. Herein, we report the first case of segmental ischaemic infarction of the iris, which occurred after autologous fat injection into the lower eyelid.
Case Presentation: A 28-year-old Korean woman complained of the discolouration of the iris after the fat injection. Slit-lamp biomicroscopy revealed segmental depigmented atrophic iris with sectoral sphincter palsy.
Conclusions: We found that iris atrophy could be caused by autologous fat transplantation. The plastic surgeons should pay more attention to possibility of fat embolism-induced ocular complications in the procedure of fat injection.
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http://dx.doi.org/10.1186/s12886-017-0599-8 | DOI Listing |
Biochem Biophys Res Commun
September 2025
Department of Ophthalmology, Hebei Medical University, NO. 361 Zhongshan East Road, Changan District, Shijiazhuang City, Hebei Province, China; Department of Ophthalmology, Hebei General Hospital, NO. 348 Heping West Road, Xinhua District, Shijiazhuang City, Hebei Province, China. Electronic address
Diabetic retinopathy (DR) is among the most prevalent complications linked to advanced diabetes. Capillary Basement membrane (CBM) thickening is an early clinical manifestation in DR, and Laminin α 1 (LAMA1) is one of the main extracellular matrix components involved in CBM formation. Dapagliflozin (DAPA) has demonstrated efficacy in ameliorating DR.
View Article and Find Full Text PDFJ Mol Histol
September 2025
Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
One of the most prevalent metabolic diseases in recent years, type 2 diabetes is now one of the top causes of death globally and a significant risk factor for cardiovascular diseases. Therefore, the goal of this study is to investigate the impact of HIIT exercises on the levels of specific proteins associated with mitochondrial biogenesis and apoptosis in the heart tissue of male Wistar rats with type 2 diabetes. Animals in diabetic groups were given a high-fat diet and an intraperitoneal injection of STZ to cause diabetes.
View Article and Find Full Text PDFPLoS One
September 2025
Plateforme de Biopharmacie, Université de Montréal, Montréal, Quebec, Canada.
Introduction: The Covid-19 pandemic has intensified shortages in various pharmaceutical products, notably injectable propofol in lipid emulsion form. Its demand surged sharply due to its critical role in intubating patients with respiratory distress during the pandemic, exposing vulnerabilities in the supply chain for this essential product.
Objectives: This project aims to develop an alternative formulation to commercially available propofol products and to evaluate its stability through a detailed study.
Front Endocrinol (Lausanne)
September 2025
Department of Obstetrics and Gynecology, Center for Reproductive Medicine, The Fourth Affiliated Hospital of School of Medicine and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, Zhejiang, China.
Background: Obesity is associated with hormonal imbalance, increased oxidative stress, and inflammation in the testis. These conditions adversely affect sperm quality, leading to impaired male fertility. Therefore, therapeutic interventions to counteract the adverse effects of obesity are crucial.
View Article and Find Full Text PDFMol Metab
September 2025
Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, 77030, USA. Electronic address:
Background And Objective: Connexin43 (Cx43), encoded by Gja1, forms gap junctions between adjacent cells. In adipose tissue, it is upregulated during adipose beiging while downregulated by high-fat-diet (HFD) feeding. Adipocyte-specific Gja1 overexpression enhances adipose tissue beiging in response to mild cold stress of room temperature.
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