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Surgical resection of the primary tumor may enhance the metastasis and recurrence of cancer. The reaction of patients to surgery includes changes of the immune system, the inflammatory system and the neuroendocrine system. In the perioperative period, anesthetics are used both for anesthesia and analgesia. There are several studies showing that the progression of cancer can be influenced by many kinds of anesthetics, although most of these studies are preclinical and thus have not yet influenced clinical recommendations. This review summarizes recent studies regarding the effects of anesthetics on metastasis and recurrence of cancer.
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http://dx.doi.org/10.14740/wjon1031e | DOI Listing |
Ned Tijdschr Geneeskd
September 2025
LUMC, Leiden, afd. Psychiatrie.
Agitated patients present a challenge in clinical practice. Management strategies vary depending on severity, ranging from (non-)verbal de-escalation to pharmacological sedation. This article outlines a stepwise approach to treating agitation, distinguishing between mild, moderate, and extreme agitation.
View Article and Find Full Text PDFInt J Surg
September 2025
Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao, Shandong Province, China.
Background: As a common postoperative neurological complication, postoperative delirium (POD) can lead to poor postoperative recovery in patients, prolonged hospitalization, and even increased mortality. However, POD's mechanism remains undefined and there are no reliable molecular markers of POD to date. The present work examined the associations of cerebrospinal fluid (CSF) sTREM2 with CSF POD biomarkers, and investigated whether the effects of CSF sTREM2 on POD were modulated by the core pathological indexes of POD (Aβ42, tau, and ptau).
View Article and Find Full Text PDFJ Virol
September 2025
Department of Hepatology, Center of Infectious Diseases and Pathogen Biology, Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, Jilin, China.
Unlabelled: Cholesterol 25-hydroxylase (CH25H), an interferon-stimulated gene (ISG), has been implicated in broad-spectrum antiviral immunity. Here, we identify CH25H as a potent suppressor of hepatitis B virus (HBV) replication that significantly outperforms IFN-α in reducing HBV DNA, pregenomic RNA (pgRNA), HBsAg, and HBeAg, without inducing cytotoxicity. However, CH25H is weakly expressed in hepatocytes and only modestly induced by type I interferon.
View Article and Find Full Text PDFInfect Control Hosp Epidemiol
September 2025
Department of Infectious Diseases, Hiroshima University Hospital, Hiroshima, Japan.
Objective: To evaluate the impact of reported β-lactam allergy on the risk of surgical site infections (SSIs), given that most reported cases are unverified and may lead to suboptimal antibiotic prophylaxis.
Design: Systematic review and meta-analysis.
Methods: Four databases were systematically searched for studies reporting SSI rates in patients with and without β-lactam allergy.
Kardiologiia
September 2025
West China Hospital of Sichuan University, Department of Cardiovascular Surgery, Sichuan University.
A middle-aged female presenting with progressive heart failure was admitted to the emergency department. She had a history of mitral and aortic valve replacement and a reoperation involving the Konno procedure. Echocardiography suggested a possible paraprosthetic leakage, which was confirmed during surgery.
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