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Despite advances in antibiotic and surgical management and supportive care for necrotizing soft tissue infections, morbidity and mortality remain substantial. Although there are clinical practice guidelines in place, there still remains much variability in choice and duration of antibiotic therapy, time to initial surgical debridement, and use of adjuvant medical therapies. This article offers an overview of necrotizing soft tissue infections with a focus on current diagnostic and treatment modalities.
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http://dx.doi.org/10.1016/j.idc.2017.05.011 | DOI Listing |
Int J Surg Case Rep
September 2025
Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Department of Biomedical Science, Faculty of Medicine, Universitas Surabaya, Indonesia.
Introduction And Importance: One of the risk factors linked to mortality in Fournier Gangrene (FG) is the elderly. When this risk is present and diagnosed too late, patient care may become difficult. This case report discusses the treatment of an older patient with late-diagnosed Fournier's gangrene and its consequences in this background.
View Article and Find Full Text PDFEur Phys J E Soft Matter
September 2025
Department of Mathematics, Indian Institute of Technology Kharagpur, Kharagpur, 721302, West Bengal, India.
Tumour growth involves dynamic interactions among tumour cells, extracellular materials, and host tissue. The tumour exerts mechanical stresses on the host tissue and simultaneously experiences compression across the tumour-host interface. This article presents a mathematical model that mimics an in vivo set-up, where an avascular tumour is surrounded by healthy/normal tissue, utilizing conservation principles for the constituents in each region.
View Article and Find Full Text PDFKlin Mikrobiol Infekc Lek
June 2025
Department of Infectious Diseases and Travel Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic, e-mail:
Skin and soft tissue infections (SSTIs) represent a diverse spectrum of conditions, including erysipelas, cellulitis, cutaneous abscesses, necrotizing fasciitis, and myonecrosis. Erysipelas and cellulitis are the most common community-acquired SSTIs. Erysipelas is typically caused by pyogenic streptococci, while cellulitis often has a staphylococcal etiology.
View Article and Find Full Text PDFJ Drugs Dermatol
September 2025
Background: Soft-tissue filler injection-related vascular complications (IRVC) can lead to tissue necrosis, vision loss, and stroke. Hyaluronidase-based injections are the mainstay of treatment, though other options include heat, massage, nitroglycerin, and anticoagulants. Given the narrow therapeutic window and limited early warning signs, we propose training residents to implement a standardized soft-tissue filler vascular complication (SFVC) management protocol.
View Article and Find Full Text PDFUgeskr Laeger
August 2025
Plastik- og Brystkirugi, Aarhus Universitetshospital.
Fournier's gangrene is a severe necrotizing soft tissue infection requiring urgent debridement and broad-spectrum antibiotics with large defects posing cosmetic and functional challenges. This review presents considerations and possibilities for reconstruction of the scrotum after heavy debridement, mainly focusing on split-thickness skin grafts and local flap techniques. While flaps provide superior cosmetic and protective outcomes, grafts are simpler and more cost-effective.
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