Structured Training of Dermatology Residents in the Management of Soft-Tissue Filler-Induced Vascular Complications.

Background: Soft-tissue filler injection-related vascular complications (IRVC) can lead to tissue necrosis, vision loss, and stroke. Hyaluronidase-based injections are the mainstay of treatment, though other options include heat, massage, nitroglycerin, and anticoagulants. Given the narrow therapeutic window and limited early warning signs, we propose training residents to implement a standardized soft-tissue filler vascular complication (SFVC) management protocol.

An estrogen-independent and IL-1-dependent pathway controls vulvovaginal candidiasis through combined IL-17/IL-22 signaling.

Vulvovaginal candidiasis (VVC), caused by the commensal pathobiont affects >75% of women, marring quality of life and incurring significant health costs. Estrogen (E2) activity is tightly linked to VVC susceptibility, and preclinical models employ E2 to establish vaginal colonization. Unlike most forms of candidiasis, VVC is not considered to be a condition of immune compromise.

Ocular complications of tussock moth cocoon associated injury.

Insect-associated intraocular foreign body (IOFB) is a rare etiology of ocular injury. Ocular exposure to tussock moth hairs, or setae, have been associated with ophthalmia nodosa, endophthalmitis, cataracts, and long-term vision loss. We present a case of a vitreous hemorrhage and tractional retinal detachment induced by Tussock moth cocoon setae.

Efficacy and Safety of Apremilast Over 52 Weeks in Patients with Plaque Psoriasis in High-Impact Areas and Impaired Quality of Life.

Introduction: In EMBRACE, significant benefits were seen with apremilast versus placebo on quality of life (QoL) and clinical outcomes after 16 weeks in patients with chronic plaque psoriasis in ≥ 1 high-impact area, limited skin involvement, and impaired QoL, in a European population previously unstudied with apremilast. Our objective was to evaluate the 52-week efficacy and safety of apremilast.

Methods: EMBRACE was a phase 4, multicenter, randomized, placebo-controlled, double-blind study.

Pancytopenia Concurrent With Metabolic Encephalopathy.

Pancytopenia is a decrease in the number of cells in all peripheral blood cell lines and has been associated with anemias, cancers, chemotherapy, infections, and nutritional deficiencies. However, pancytopenia concurrent with encephalopathy is rare and not well-studied. We present a case of pancytopenia concurrent with metabolic encephalopathy.

Monocyte Production of C1q Potentiates CD8 T-Cell Function Following Respiratory Viral Infection.

Respiratory viral infections remain a leading cause of morbidity and mortality. Using a murine model of human metapneumovirus, we identified recruitment of a C1q-expressing inflammatory monocyte population concomitant with viral clearance by adaptive immune cells. Genetic ablation of C1q led to reduced CD8 T-cell function.

Management of Idiopathic Infantile Chylous Ascites.

Chylous ascites is the accumulation of triglyceride-rich lymphatic fluid in the peritoneal cavity. We present the case of a four-month-old male admitted for abdominal distension. A large volume of ascites was confirmed by imaging.

Scleroderma after COVID-19 Infection and Vaccination.

Scleroderma is a rare autoimmune connective tissue disorder characterized by fibrotic hardening and tightening of the skin. Scleroderma develops as a drug-induced and paraneoplastic phenomenon; however, scleroderma associated with COVID-19 has been rarely discussed. We present an updated review of scleroderma after the COVID-19 infection and vaccination.

Toxic epidermal necrolysis and Stevens-Johnson syndrome after COVID-19 infection and vaccination.

Stevens-Johnson Syndrome (SJS) is a rare but severe skin reaction characterized by blistering and peeling of the skin and ulcerations of mucous membranes; toxic epidermal necrolysis (TEN) is a subset of SJS characterized by the involvement of >30% of the skin. Though previously associated with drugs and infections, discussions on the association between TEN/SJS and COVID-19 have been limited. We present a review of TEN/SJS after COVID-19 infection and vaccination.

Lichen planus after COVID-19 infection and vaccination.

Lichen planus (LP) is an inflammatory disorder believed to result from CD8 + cytotoxic T-cell (CTL)-mediated autoimmune reactions against basal keratinocytes. We present a review of LP following COVID-19 infection and vaccination. Literature searches were conducted on PubMed and Google Scholar from 2019 to 7/2022.

Advanced thallium toxicity.

Thallium is a highly toxic tasteless, odourless and water-soluble metal that can be absorbed through the skin, inhaled or ingested. Due to the rarity of thallium toxicity, it is frequently misdiagnosed or the diagnosis is delayed. We report a 41-year-old male landscaper admitted for acute polyneuropathy and abdominal pain.

Chylothorax After Schwannoma Resection.

Schwannomas are tumors derived from Schwann cells of the peripheral nerve sheath that are usually benign; nonetheless, they can cause significant morbidity. When indicated, surgical resection is the gold standard of treatment for schwannomas. However, chylothorax is a rare postoperative complication of thoracic surgery.

Left Ovarian Cyst With Overlying Sigmoid Colon.

Ovarian cysts are usually asymptomatic and self-resolvable, but large cysts can increase the risk of ovarian torsion or rupture and may be indicated for surgical intervention. We present the case of a large left ovarian cyst in which laparoscopic left salpingo-oophorectomy was challenged by an overlying sigmoid colon with dense adhesions. A 47-year-old female patient presented to the emergency department with abdominal pain in the right lower quadrant.

Exudative Retinal Detachment After ROP Laser Photocoagulation.

Exudative retinal detachment (ERD) can be a rare postoperative complication of laser photocoagulation surgery when used to treat type I retinopathy of prematurity (ROP). We present a case of bilateral ERD following ROP laser photocoagulation. A preterm male infant born at 24 weeks gestation and weighing 600 grams was diagnosed with stage 3/zone II/pre-plus ROP in both eyes.