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Using the planar 1,8-naphthyridin-2(1H)-one (Hnpo) ligand, novel nonhelical HMSCs [MoM(npo)(NCS)] (M = Fe, Co, Ni) were synthesised and they exhibited high single-molecule conductance.
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http://dx.doi.org/10.1039/c7cc05449a | DOI Listing |
Angew Chem Int Ed Engl
September 2025
Institute of Modern Optics and Center of Single-Molecule Science, Tianjin Key Laboratory of Micro-scale Optical Information Science and Technology, Nankai University, Tianjin, 300350, China.
Radical coupling reactions have been widely used in the synthesis of complex organic molecules, materials science, and drug research. However, restricted conditions or special catalysts are required to overcome the energy barrier and trigger the coupling reaction efficiently. In this study, we provide experimental evidence that the C─N radical coupling reactions can be significantly accelerated by an oriented external electric field (OEEF) under synchronous UV irradiation without a catalyst.
View Article and Find Full Text PDFTalanta
August 2025
School of Public Health &Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330031, PR China. Electronic address:
Hemorrhagic fever with renal syndrome (HFRS), caused by Hantaan virus, poses a serious public health threat. Current diagnostic methods remain limited by low sensitivity, complex procedures, and high sample requirements. To address this, we developed a highly sensitive single-molecule biosensor using multi-fluorophore nucleic acid probes and STORM imaging for the detection of Hantaan virus RNA.
View Article and Find Full Text PDFTranscription factors regulate gene expression with DNA-binding domains (DBDs) and activation domains. Despite mounting evidence to the contrary, it is frequently assumed that DBDs are solely responsible for interacting with DNA and chromatin. Here, we used single-molecule tracking of transcription factors in living cells to show that short activation domains can control the fraction of molecules bound to chromatin.
View Article and Find Full Text PDFbioRxiv
August 2025
Department of Biochemistry and Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Pathogenic variants in the motor domain of the kinesin-3 motor protein KIF1A cause a range of neurodevelopmental and neurodegenerative conditions collectively termed KIF1A-associated neurological disorder (KAND). Among these, mutations at residue R350 are linked to hereditary spastic paraplegia and altered motor function. Yet, the structural basis for their pathogeny remains unclear.
View Article and Find Full Text PDFJ Phys Chem Lett
September 2025
Department of Chemistry and Biochemistry, Kent State University, Kent, Ohio 44242, United States.
Liquid-liquid phase separation (LLPS) is a newly discovered phenomenon to modulate a multitude of cellular functions. Despite its importance, the full evolution mechanism of LLPS starting from intramolecular interactions to intermolecular condensations has yet to be revealed. In this study, we investigated a representative LLPS formed between negatively charged nucleic acids poly(G-quadruplex) and positively charged peptides poly(lysine).
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