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http://dx.doi.org/10.1038/emi.2017.10 | DOI Listing |
Cancer Sci
August 2025
Department of Cancer Cell Biology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Melanoma heterogeneity contributes to increased metastatic potential. Although a subpopulation characterized by MITF/AXL has been linked to invasiveness, the underlying mechanisms remain unclear. In this study, we identified cell migration-related gene sets as significantly enriched after the knockdown of SOX10 in melanoma.
View Article and Find Full Text PDFBiochim Biophys Acta Proteins Proteom
September 2025
RayBiotech Inc, 3607 Parkway Lane, Peachtree Corners, Atlanta, GA 30092, USA; RayBiotech Guangzhou Co. Ltd. Guangzhou, Guangzhou 510000, China. Electronic address:
The binding of the SARS-CoV-2 spike (S) glycoprotein to human host receptors, including ACE2, NRP1, and AXL, is essential for viral entry. Glycosylation of both the spike protein and its host receptors can significantly influence these interactions. While NRP1 is recognized as a key host receptor, the role of its glycosylation in spike binding and viral infectivity has not been fully elucidated.
View Article and Find Full Text PDFTheranostics
June 2025
Department of Neurosurgery & Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Hematoma volume significantly influences the prognosis of patients with intracerebral hemorrhage (ICH). Effective resolution of hematoma through enhanced clearance mechanisms and reduced hematoma lysis is essential for neurological recovery following ICH. Regulatory T cells (Tregs), known for their anti-inflammatory properties, exert neuroprotective effects in various central nervous system disorders.
View Article and Find Full Text PDFCell Death Discov
June 2025
Center of Emergency and Critical Medicine, Jinshan Hospital of Fudan University, Shanghai, 201508, China.
Sepsis-associated encephalopathy (SAE) is a severe complication marked by acute central nervous system (CNS) injury and neuroinflammation. M2 microglia efferocytosis is essential for resolving neuroinflammation, but its regulatory mechanisms remain unclear. This study explored the GAS6/AXL signaling pathway in SAE, hypothesizing its role in enhancing anti-inflammatory responses and efferocytosis.
View Article and Find Full Text PDFArthritis Rheumatol
June 2025
Department of Rheumatology and Immunology, Second Xiangya Hospital of Central South University and Clinical Medical Research Center for Systemic Autoimmune Diseases in Hunan Province, Changsha, China.
Efferocytosis, the process through which phagocytes clear apoptotic cells (ACs), has rapidly emerged as an expanding field of research. This multistep process involves recognizing, binding, internalizing, and degrading ACs. Efferocytosis clears ACs, preventing their secondary necrosis, generating anti-inflammatory mediators, and promoting the resolution of inflammation.
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