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http://dx.doi.org/10.3390/ph10020033 | DOI Listing |
Nucleic Acids Res
September 2025
Department of Pathology, Microbiology and Immunology, College of Medicine, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, NE 68198-5900, United States.
The global antibiotic resistance issue constitutes a driving force for developing host defense antimicrobial peptides (AMPs) into a new generation of antibiotics. To facilitate this development, we report the antimicrobial peptide database version 6 (APD6) with (i) the consolidated database platform, (ii) the most comprehensive AMP information pipeline (AMPIP), and (iii) the expanded wheel of function. As of 18 March 2025, the APD6 platform housed records for 5188 peptides, including 3306 natural, 1380 synthetic, and 239 predicted AMPs with systematic classification schemes for each group.
View Article and Find Full Text PDFHealth Inf Manag
September 2025
World Health Organisation, Switzerland.
Background: ICD-11's digital architecture and granularity distinguish it from previous revisions and expand its applicability beyond mortality statistics and public health. The official ICD-11 version is updated annually. However, a separate online Maintenance Platform is continuously updated and hosts the Proposal Platform: a novel online tool that enables interested parties from all over the world to contribute to ICD-11 content.
View Article and Find Full Text PDFAm J Physiol Cell Physiol
September 2025
Humboldt-University zu Berlin, Berlin, Germany.
Skeletal muscle atrophy and weakness are major contributors to morbidity, prolonged recovery, and long-term disability across a wide range of diseases. Atrophy is caused by breakdown of sarcomeric proteins resulting in loss of muscle mass and strength. Molecular mechanism underlying the onset of muscle atrophy and its progression have been analysed in patients, mice, and cell culture but the complementarity of these model systems remains to be explored.
View Article and Find Full Text PDFUnfallchirurgie (Heidelb)
September 2025
Klinik für Orthopädie, Unfall- und Wiederherstellungschirurgie, Uniklinik RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Deutschland.
The treatment of polytraumatized patients is challenging. Intensive efforts and interdisciplinary teamwork have improved survival rates of severely injured patients over the last decades. High quality guideline recommendations focusing on the prehospital setting, emergency room management and also the initial surgical phase have been published and are frequently updated.
View Article and Find Full Text PDFBioinformatics
September 2025
School of Computer Science and Technology, Beijing Institute of Technology, Beijing, 100081, China.
Motivation: Therapeutic peptide is an important ingredient in the treatment of various diseases and drug discovery. The toxicity of peptides is one of the major challenges in peptide drug therapy. With the abundance of therapeutic peptides generated in the post-genomics era, it is a challenge to promptly identify toxicity peptides using computational methods.
View Article and Find Full Text PDF