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Vitamin A supplementation (VAS) programs targeted at children aged 6-59 months are implemented in many countries. By improving immune function, vitamin A (VA) reduces mortality associated with measles, diarrhea, and other illnesses. There is currently a debate regarding the relevance of VAS, but amidst the debate, researchers acknowledge that the majority of nationally-representative data on VA status is outdated. To address this data gap and contribute to the debate, we examined data from 82 countries implementing VAS programs, identified other VA programs, and assessed the recentness of national VA deficiency (VAD) data. We found that two-thirds of the countries explored either have no VAD data or data that were >10 years old (i.e., measured before 2006), which included twenty countries with VAS coverage ≥70%. Fifty-one VAS programs were implemented in parallel with at least one other VA intervention, and of these, 27 countries either had no VAD data or data collected in 2005 or earlier. To fill these gaps in VAD data, countries implementing VAS and other VA interventions should measure VA status in children at least every 10 years. At the same time, the coverage of VA interventions can also be measured. We identified three countries that have scaled down VAS, but given the lack of VA deficiency data, this would be a premature undertaking in most countries without appropriate status assessment. While the global debate about VAS is important, more attention should be directed towards individual countries where programmatic decisions are made.
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http://dx.doi.org/10.3390/nu9030190 | DOI Listing |
Eur J Public Health
September 2025
Danish Health Data Authority, Copenhagen, Denmark.
European Union (EU) Member States face challenges in using health data for secondary purposes, constrained by inconsistent digital health systems and limited cross-border sharing. One aim of the European Health Data Space (EHDS) is to facilitate secondary health data use through the HealthData@EU infrastructure and Health Data Access Bodies (HDABs). This article provides recommendations essential for HDAB implementation, informed by the HealthData@EU Pilot project.
View Article and Find Full Text PDFAnn Biomed Eng
September 2025
Department of Mechanical Engineering, Koc University, Rumeli Feneri Campus, Sarıyer, 34450, Istanbul, Turkey.
Purpose: The design and development of ventricular assist devices have heavily relied on computational tools, particularly computational fluid dynamics (CFD), since the early 2000s. However, traditional CFD-based optimization requires costly trial-and-error approaches involving multiple design cycles. This study aims to propose a more efficient VAD design and optimization framework that overcomes these limitations.
View Article and Find Full Text PDFAlzheimers Dement
September 2025
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Introduction: Midlife hypertension is associated with dementia risk, although uncertainties remain regarding its association with subtypes and regarding the effect of pregnancy-related hypertension on dementia risk.
Methods: In the Million Women Study, 1,363,457 women (mean age 57) were asked about current treatment for hypertension and hypertension in pregnancy and were followed for first hospital record with any mention of dementia. Cox regression yielded hazard ratios (HRs) adjusted for socioeconomic, lifestyle, and metabolic factors.
J Neurol
September 2025
Department of Neurology & Innovation Center for Neurological Disorders, National Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Beijing, 100053, China.
Background: Sleep deprivation has been linked to higher dementia risk, but the role of weekend recovery sleep (WRS) in mitigating this risk remains unclear. This study aims to evaluate the association between WRS and dementia risk.
Methods: This prospective cohort study followed 88,592 dementia-free adults aged 40-79 years from the UK Biobank, using wrist accelerometers to measure average weekday and weekend sleep durations.
Front Nutr
August 2025
Clinical Medical College and Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Objective: The current systematic research on the disease burden of Vitamin A deficiency in China is limited. To analyze the trends in the disease burden of Vitamin A Deficiency (VAD) in China from 1990 to 2021 and predict future trends from 2022 to 2050, providing a scientific basis for the prevention of VAD in China.
Methods: Based on the Global Burden of Disease (GBD) data, we extracted incidence, prevalence, and disability-adjusted life years (DALYs) for VAD in China from 1990 to 2021.