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What's already known about this topic? Several countries, including the Netherlands, have implemented non‐invasive prenatal testing (NIPT) in their national prenatal screening program. Access to relevant online health information is important as it increases informed decision making. What does this study add? Visitors of national NIPT websites mostly request more information about testing beyond the currently available NIPT: a broader range of disorders (such as monogenic disorders) and increasing target group eligibility (such as low‐risk or twin pregnancies). © 2017 The Authors. published by John Wiley & Sons, Ltd.
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http://dx.doi.org/10.1002/pd.5011 | DOI Listing |
Nano Lett
September 2025
School of Electrical Engineering, Southwest Jiaotong University, Chengdu 610032, People's Republic of China.
Precise modulation of the electronic structure in transition metals, particularly the d-band center position and spin state, remains a critical challenge to expediting hydrogen evolution reaction (HER) kinetics. Herein, we report a NiPt/Ni-heterostructured catalyst enabling simultaneous optimization of the d-band electronic structure and spin state of Ni through regulation of the NiPt and Ni bridge sites. Combining operando spectroscopy, X-ray absorption spectroscopy, density functional theory, and ab initio molecular dynamics simulations, we establish that the coordination environment and spin states of Ni at the bridge sites were effectively modulated by altering the Pt content, achieving a transition of Ni centers from the low-spin to high-spin state, and optimized intermediate adsorption/desorption behaviors.
View Article and Find Full Text PDFPurpose: Fetal cells in maternal blood are a pure source of fetal genomic DNA for noninvasive prenatal testing (NIPT), if successfully isolated. We assessed whether single-cell genome and transcriptome sequencing (G&T-seq) can be applied to efficiently isolate fetal nucleated red blood cells (fNRBCs) suitable for genetic testing.
Methods: Using umbilical cord blood as a model, we isolated 165 single NRBC candidates from four samples and 12 single lymphocytes as controls from one sample.
Clin Chim Acta
August 2025
National Translational Science Center for Molecular Medicine and Department of Cell Biology, Air Force Medical University, Xi'an, Shaanxi 710032, China. Electronic address:
Digital PCR (dPCR) has demonstrated significant potential in non-invasive prenatal testing (NIPT) due to its high sensitivity and ability to provide absolute quantification of low-abundance targets. This review explores the broad applications of dPCR in NIPT, highlighting its advantages, particularly in identifying low-abundance fetal DNA and analyzing complex genetic variations. To further enhance its clinical utility, improvements are needed in detection sensitivity, multi-target analysis optimization, cost reduction, operational simplification, and standardization.
View Article and Find Full Text PDFPrenat Diagn
July 2025
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, China.
Objective: To identify risk factors associated with noninvasive prenatal testing (NIPT) failures due to a low fetal fraction (LFF, < 4%) and to evaluate appropriate management strategies.
Methods: This was a single retrospective cohort study conducted on consecutive NIPT procedures performed at a national prenatal diagnosis center between April 2016 and June 2022.
Results: Among the 41,693 NIPT procedures conducted at Peking Union Medical College Hospital, 524 cases (1.
J Community Genet
July 2025
amedes MVZ wagnerstibbe, Hannover, Germany.
Non-invasive prenatal testing (NIPT) for fetal chromosomal aberrations is an important component of healthcare systems worldwide, albeit with varying diagnostic coverage and conditions of use. In Germany, NIPT primarily focuses on trisomies 21, 18 and 13, for which the test costs are reimbursed by the statutory health insurance after thorough prior counseling. Despite this rather restrictive approach compared to other countries, concerns continue to be raised in Germany that young pregnant women, in particular, who are at a low risk of fetal aneuploidy, may have been overly encouraged to undergo NIPT.
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