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This paper presents the development of a smart walker that uses a formation controller in its displacements. Encoders, a laser range finder and ultrasound are the sensors used in the walker. The control actions are based on the user (human) location, who is the actual formation leader. There is neither a sensor attached to the user's body nor force sensors attached to the arm supports of the walker, and thus, the control algorithm projects the measurements taken from the laser sensor into the user reference and, then, calculates the linear and angular walker's velocity to keep the formation (distance and angle) in relation to the user. An algorithm was developed to detect the user's legs, whose distances from the laser sensor provide the information necessary to the controller. The controller was theoretically analyzed regarding its stability, simulated and validated with real users, showing accurate performance in all experiments. In addition, safety rules are used to check both the user and the device conditions, in order to guarantee that the user will not have any risks when using the smart walker. The applicability of this device is for helping people with lower limb mobility impairments.
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http://dx.doi.org/10.3390/s16071116 | DOI Listing |
Anaesthesia
September 2025
Department of Applied Health Sciences, School of Health Sciences, University of Birmingham, UK.
Introduction: Restoration of surgical capacity is essential to post-COVID-19 recovery. This study explored the use and safety of anaesthesia options for inguinal hernia surgery, a common tracer condition, to describe current global practice and highlight opportunities to build the capacity of health systems.
Methods: This is a secondary analysis of an international prospective cohort study of consecutive patients who underwent elective inguinal hernia surgery.
Background: Sotrovimab is a neutralising monoclonal antibody targeting the SARS-CoV-2 spike protein. We aimed to evaluate the efficacy and safety of sotrovimab in the RECOVERY trial, an investigator-initiated, individually randomised, controlled, open-label, adaptive platform trial testing treatments for patients admitted to hospital with COVID-19.
Methods: Patients admitted with COVID-19 pneumonia to 107 UK hospitals were randomly assigned (1:1) to either usual care alone or usual care plus a single 1 g infusion of sotrovimab, using web-based unstratified randomisation.
Biosens Bioelectron
December 2025
State Key Laboratory of Flexible Electronics (LoFE), Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing, 210023, China. Electronic address:
Accurate quantification of cancer-related miRNA in exosomes offers a promising approach for early and effective cancer diagnosis. However, reliably detecting extremely low-abundance exosomal miRNAs in complex bodily fluids remains a significant challenge. Herein, a CRISPR/Cas13a triggered-DNA walker amplified SERS sensor has been proposed for detection of cancer cell-derived exosomal miRNA-106a.
View Article and Find Full Text PDFDiabetes Care
August 2025
Coordinating Center, Biostatistics Center, The George Washington University, Rockville, MD.
Objective: To determine the effects of first-degree family history of diabetes on diabetes incidence in Diabetes Prevention Program (DPP) and Diabetes Prevention Program Outcomes Study (DPPOS) participants.
Research Design And Methods: In the DPP, adults with prediabetes were randomized to an intensive lifestyle intervention, metformin, or placebo and followed for incident diabetes. On study completion 88% of eligible DPP participants reenrolled in DPPOS for long-term follow-up.
Diabetes Care
August 2025
Department of Biostatistics and Bioinformatics, Milken Institute School of Public Health, The George Washington University, Rockville, MD.
The Diabetes Prevention Program (DPP) was a 3-year randomized clinical trial (RCT) with evaluation of lifestyle and metformin interventions compared with placebo for diabetes prevention in high-risk adults. Both interventions significantly reduced diabetes incidence, prompting the long-term Diabetes Prevention Program Outcomes Study (DPPOS) to assess the progression of diabetes and its complications over 22 years. During follow-up, departures from the original metformin or placebo assignment occurred primarily because of development of diabetes that, by protocol, was managed by clinicians outside the study, after participants developed diabetes with HbA1c ≥7.
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