Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
In biochemical networks transient dynamics plays a fundamental role, since the activation of signalling pathways is determined by thresholds encountered during the transition from an initial state (e.g. an initial concentration of a certain protein) to a steady-state. These thresholds can be defined in terms of the inflection points of the stimulus-response curves associated to the activation processes in the biochemical network. In the present work, we present a rigorous discussion as to the suitability of finite-time Lyapunov exponents and metabolic control coefficients for the detection of inflection points of stimulus-response curves with sigmoidal shape.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/17513758.2016.1204016 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Role of and AMPK Signaling Pathway in Sarcopenia.
Int J Gen Med
August 2025
Department of Geriatric Medicine, Changsha Central Hospital, Changsha, Hunan, 410000, People's Republic of China.
Objective: To identify the hub genes involved in sarcopenia and analyze their correlation with lipid metabolism.
Methods: Differentially expressed genes (DEGs) from sarcopenia/non-sarcopenia cohorts in and datasets were cross-analyzed with diabetes-related genes (GeneCards). Key genes underwent functional enrichment and protein-protein interaction (PPI) network analysis.
Gene regulatory logic of the interferon-β enhancer is characterized by two selectively deployed modes of transcription factor synergy.
Proc Natl Acad Sci U S A
August 2025
Signaling Systems Laboratory, Department of Microbiology, Immunology and Molecular Genetics, and the Institute for Quantitative and Computational Biosciences, University of California Los Angeles, CA 90095.
Type I interferon IFNβ is a key immune response cytokine, and when its expression is dysregulated, it causes disease. The regulation of IFNβ enhancer has been a touchpoint of mammalian gene control research since the discovery of functional synergy between two stimulus-responsive transcription factors (TFs), nuclear factor kappa B (NFκB) and interferon regulatory factors (IRF). However, subsequent gene knockout studies revealed that in some conditions either NFκB or IRF activation can be dispensable, leaving the precise regulatory logic of IFNβ transcription an open question.
View Article and Find Full Text PDFChanges in corticospinal excitability of shoulder muscles across functional glenohumeral joint positions.
J Neurophysiol
August 2025
Department of Kinesiology, Brock University, St. Catharines, Ontario, Canada.
The shoulder is a complex region of the body that can be prone to injury associated with awkward postures due to a broad range of motion and relatively low stability. A better understanding of how arm orientation influences neural drive (excitability) to muscles surrounding the glenohumeral joint can provide insight into recruitment strategies. The purpose of this study was to determine the influence of glenohumeral joint angle on excitability of the muscles surrounding the shoulder complex.
View Article and Find Full Text PDFComparing motor unit number estimation techniques.
J Electromyogr Kinesiol
October 2025
School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, Canada. Electronic address:
It is unclear how comparable motor unit number estimates (MUNEs) are when derived from a non-invasive technique involving repetitive peripheral nerve stimulation vs. one involving volitional contractions and intramuscular recordings of single motor units (MUs). Therefore, this study examined MUNEs from MScanFit (MScan) and Decomposition-Enhanced Spike-Triggered Averaging (DE-STA).
View Article and Find Full Text PDFPropofol inhibits Piezo mechanosensitive channels.
Biophys J
June 2025
School of Electrical, Computer, and Biomedical Engineering, Southern Illinois University Carbondale, Carbondale, Illinois. Electronic address:
Modulation of ion channels is a key mechanism by which anesthetics exert their effects. Propofol, a widely used anesthetic, has been shown to influence mechanosensitive ion channels, although the details of this interaction remain under investigation. In this study, we show that propofol inhibits Piezo mechanosensitive channels using electrophysiological recordings and calcium imaging in HEK293T cells overexpressing human Piezo1 (hP1) and Piezo2 (hP2) channels.
View Article and Find Full Text PDF