Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

[This corrects the article DOI: 10.1371/journal.pgen.1005378.].

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927064PMC
http://dx.doi.org/10.1371/journal.pgen.1006166DOI Listing

Publication Analysis

Top Keywords

correction influence
4
influence age
4
age sex
4
sex genetic
4
genetic associations
4
associations adult
4
adult body
4
body size
4
size shape
4
shape large-scale
4

Similar Publications

Introduction: The complement receptor 1 (CR1) gene is identified as the one closely associated with Alzheimer's disease (AD). However, there has been no exploration of the imaging alterations associated with the CR1 gene in AD patients of the Han population. The purpose of this study is to investigate the association between the rs6656401 mutation and neuroimaging variations in Han AD patients.

View Article and Find Full Text PDF

Global phosphorus (P) resources are facing a depletion crisis, and pyrolysis of P-rich sewage sludge (SS) offers significant resource potential. Optimizing pyrolysis conditions remains key yet challenging for enhancing P retention and bioavailability. This study conducted a correlation-prediction-causation integrated framework (CPCIF) to investigate how heating temperature (HT), heating rate (HR), and retention time (RT) influence total P enrichment rate (BTPE), relative inorganic P transformation rate (BITP), and relative apatite P transformation rate (BAIP) from SS to biochar during pyrolysis.

View Article and Find Full Text PDF

Enhancing D retention index accuracy: Correcting D retention time shifts in GC×GC due to modulation timing deviations via line detection technology.

Anal Chim Acta

November 2025

School of Pharmacy, Tongji Medical College, Huazhong University of Science & Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, PR China. Electronic address:

Even small deviations in modulation timing (DMT) can cause discrepancies between the originally set modulation period (P) and the actual P in comprehensive two-dimensional gas chromatography (GC × GC) analysis. This study explored the impact of DMT on the accuracy of the second dimensional retention time (t) and the second dimensional retention index (I) calculations and introduced a line detection technology (LDT) based on the Hough Transform to correct DMT-induced t shifts. The correction was achieved by automatically adjusting candidate P values until the slope of the line(s) (CB_line(s)) formed by column bleeding compound peaks in the isothermal section of the contour plot approached zero, thereby determining the actual P.

View Article and Find Full Text PDF

Optimizing protein folding in prokaryotes: Strategies to enhance soluble expression of recombinant proteins.

Bioresour Technol

September 2025

State Key Laboratory of Food Science and Resources, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China; School of Biotechnology and Key Laboratory of Industrial Biotechnology Ministry of Education, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China; International Joint Laboratory on Fo

Recombinant proteins have been widely applied in the food, biomedical, and scientific fields. Prokaryotic expression systems are preferred platforms for recombinant protein production due to their rapid growth and high protein yields. Nevertheless, disparities between recombinant expression environment and native physiological conditions frequently result in protein misfolding, leading to aggregation into non-functional inclusion bodies or proteolytic degradation.

View Article and Find Full Text PDF