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We present a novel algorithm for the simultaneous segmentation and anatomical labeling of the cerebral vasculature. Unlike existing approaches that first attempt to obtain a good segmentation and then perform labeling, we optimize for both by simultaneously taking into account the image evidence and the prior knowledge about the geometry and connectivity of the vasculature. This is achieved by first constructing an overcomplete graph capturing the vasculature, and then selecting and labeling the subset of edges that most likely represents the true vasculature. We formulate the latter problem as an Integer Program (IP), which can be solved efficiently to provable optimality. We evaluate our approach on a publicly available dataset of 50 cerebral MRA images, and demonstrate that it compares favorably against state-of-the-art methods.
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http://dx.doi.org/10.1016/j.media.2016.03.006 | DOI Listing |
Comput Methods Programs Biomed
August 2025
Zhengzhou University, School of Computer and Artificial Intelligence, Zhengzhou, 450001, China. Electronic address:
Background And Objective: The early detection of breast cancer plays a critical role in improving survival rates and facilitating precise medical interventions. Therefore, the automated identification of breast abnormalities becomes paramount, significantly enhancing the prospects of successful treatment outcomes. To address this imperative, our research leverages multiple modalities such as MRI, CT, and mammography to detect and screen for breast cancer.
View Article and Find Full Text PDFCureus
August 2025
Emergency Medicine, Stockport NHS Foundation Trust, Stockport, GBR.
Kounis syndrome, also known as allergic myocardial infarction, is a rare but potentially life-threatening condition in which acute coronary events are triggered by an allergic reaction. The pathophysiology involves mast cell degranulation and the release of inflammatory mediators such as histamine, leukotrienes, and platelet-activating factor, leading to coronary vasospasm, myocardial ischemia, or infarction. We present the case of a female patient in her 80s with no prior history of coronary artery disease who developed anaphylaxis shortly after intravenous administration of co-amoxiclav in the emergency department.
View Article and Find Full Text PDFIEEE Trans Pattern Anal Mach Intell
September 2025
Generalized visual grounding tasks, including Generalized Referring Expression Comprehension (GREC) and Segmentation (GRES), extend the classical visual grounding paradigm by accommodating multi-target and non-target scenarios. Specifically, GREC focuses on accurately identifying all referential objects at the coarse bounding box level, while GRES aims for achieve fine-grained pixel-level perception. However, existing approaches typically treat these tasks independently, overlooking the benefits of jointly training GREC and GRES to ensure consistent multi-granularity predictions and streamline the overall process.
View Article and Find Full Text PDFVestn Oftalmol
September 2025
Krasnov Research Institute of Eye Diseases, Moscow, Russia.
Modern surgical strategies for keratoconus aim to both stabilize disease progression and correct induced refractive errors. Effectively and simultaneously achieving both goals remains a relevant challenge. This study presents a clinical case of femtosecond laser-assisted intrastromal keratoplasty with implantation of a biosynthetic complex, demonstrating the efficacy of this surgical approach in treating keratoconus.
View Article and Find Full Text PDFJ Neurosci Methods
September 2025
Bioengineering College of Chongqing University, Chongqing University Central Hospital (Chongqing Emergency Medical Center), Chongqing, China; Chongqing Key Laboratory of Emergency Medicine, Chongqing, China. Electronic address:
Background: Current neurovascular unit isolation requires processing brain microvascular endothelial cells (BMECs) and neurons from separate animals, preventing concurrent analysis of neurovascular crosstalk within identical genetic/physiological contexts.
New Methods: We developed an enzymatic digestion/bovine serum albumin density gradient technique that enables the simultaneous isolation of neural tissue and microvascular segments from individual mice. The neural tissue was filtered and centrifuged for primary cortical neuron culture on poly-L-lysine-coated plates.