Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Pupose: To determine predictive factors of spontaneous closure or size reduction in large secundum-type atrial septal defects (ASD) diagnosed in infancy prior to catheterization or surgical intervention.
Methods: From June 2003 to October 2009, 59 infants diagnosed with secundum-type ASDs measuring ≥ 8 mm in the first year of life were retrospectively enrolled. We reviewed medical records, as well as electrocardiography and echocardiography findings. Patients were divided into 2 groups according to the last ASD size: group A (n = 23), ASD reduction in size to < 5 mm or spontaneous closure; group B (n = 36), size of ASD remained ≥ 5 mm.
Results: The ASDs spontaneously closed in 10 (17%) patients at a median age of 26.0 ± 5.1 months (range, 15-58 months), or decreased to < 5 mm in 13 (22%) (range, 6-27 months) patients. There was a significant difference in age at diagnosis between the 2 groups (p = 0.014). Patients in group A were younger than those in group B at the time of diagnosis. Changes in ASD size (p < 0.001) and body weight percentile (p = 0.01) were also significantly different fromthe 6-month follow-up. ASD diameter of ≥ 10 mm was a negative predictive factor for size reduction (p = 0.017).
Conclusions: Spontaneous closure or size reduction of large ASDs was not uncommon in patients diagnosed during infancy. Patients with initial ASD sizes between 8 and 10 mm who were younger at the time of diagnosis and showed better weight gain were more likely to have favorable outcomes.
Key Words: Infancy; Large secundum atrial septal defect; Natural course; Spontaneous closure.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804964 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Use of a novel zipper device for wound closure of cutaneous abscesses in pediatric outpatients: a case series.
Wounds
August 2025
Department of Day Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorder, Chongqing, China; China International Science and Technology Coopera
Background: Current management of pediatric cutaneous abscesses involves either spontaneous healing by secondary intention or suturing through tertiary intention, which are often lengthy processes that cause discomfort and distress among children. As it is noninvasive and simple, a novel zipper device is widely used for the primary wound closure of surgical incisions.
Objective: To describe the effectiveness of novel zipper device use for pediatric cutaneous abscess wound closure in an outpatient context.
The Use of Intraoperative Neuromonitoring in Anterior Cervical Spine Procedures for Myelopathy: Alert Incidence, Interventions, and Prognostic Value.
Clin Spine Surg
September 2025
Department of Orthopaedics and Physical Medicine, Medical University of South Carolina, Jonathan Lucas Street, Charleston, SC.
Study Design: Retrospective review.
Objective: Examine the utility of intraoperative neuromonitoring (IONM) in anterior cervical spine procedures for myelopathy in informing intraoperative interventions.
Summary Of Background Data: The routine use of IONM in anterior cervical spine procedures for myelopathy remains controversial, with poorly defined indications and limited evidence validating protocols for managing intraoperative alerts.
Face mask versus nasal mask device use for initial resuscitation in extremely and very preterm infants (FONDUE): an open-label, single-centre, randomised, controlled trial.
Lancet Child Adolesc Health
October 2025
The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia; Monash Newborn, Monash Children's Hospital, Melbourne, VIC, Australia; Department of Paediatrics, Monash University, Melbourne, VIC, Australia.
Background: More than 85% of very preterm infants (born <32 weeks' gestation) breathe spontaneously within 1 min of birth, however, more than 60% of infants receive positive pressure ventilation. Face mask application soon after birth might suppress breathing through the trigeminal nerve reflex, causing vocal cord closure and hypoxia. We aimed to investigate whether nasal mask continuous positive airway pressure (nCPAP) would improve CPAP success, reducing the need for positive pressure ventilation and intubation at birth, compared with face mask CPAP (fCPAP).
View Article and Find Full Text PDFEsophageal stenting and endoscopic vacuum therapy for esophageal defects: a systematic review and meta-analysis of observational studies.
Ann Med Surg (Lond)
September 2025
Department of Medicine, BPP University, United Kingdom.
Background: Spontaneous esophageal perforation, especially Boerhaave syndrome, carries high morbidity and mortality. Minimally invasive treatments like esophageal stenting and endoscopic vacuum therapy (EVT) are increasingly used, but optimal management remains unclear.
Objective: This systematic review and meta-analysis evaluates the efficacy and safety of esophageal stenting and EVT in managing esophageal defects by assessing sealing rates, failure rates, and mortality.
A Clinical Fallacy: Myth of Meningitis-Driven Dural Healing in Post-traumatic Cerebrospinal Fluid Leaks.
Cureus
July 2025
Neurosurgery, Hamad Medical Corporation, Doha, QAT.
This systematic review evaluates the management of cerebrospinal fluid (CSF) leaks following traumatic skull base fractures and examines the associated risk of post-traumatic meningitis (PTM). It also critically investigates the debated hypothesis that meningitis may promote spontaneous closure of defects in the dura mater through inflammation-induced healing. A comprehensive literature search was performed using PubMed, Scopus, and the Cochrane Library according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
View Article and Find Full Text PDF