Publications by authors named "Kuan-Miao Lin"
Article Synopsis
- A study in Taiwan examined pregnancy outcomes in women with congenital heart disease (CHD) and their children from 2009-2017, identifying 2990 women with 4227 births, categorized into groups based on CHD severity.
- Results showed that women with CHD face significant risks such as stillbirth and preterm birth, and the severity of their condition impacts the health of their offspring, with higher risks of congenital heart defects in children born to women with severe CHD.
- The study suggests that women with CHD should receive enhanced monitoring of heart function during pregnancy, including thorough assessments of fetal health and potential genetic counseling, particularly for those with severe CHD.
Article Synopsis
- Kawasaki disease (KD) is a condition in children characterized by prolonged fever and five specific clinical symptoms, with a focus on understanding its characteristics in Taiwan through a extensive cohort study.
- The analysis of data from Taiwan's National Health Insurance Research Database revealed 13,260 KD patients, with a majority under 5 years old and a notable peak incidence in May.
- The study highlighted a significant increase in KD cases over the years and introduced a helpful mnemonic device for easier diagnosis, emphasizing key factors like fever duration and age group.
Background: Acute fulminant myocarditis (AFM) commonly presents as abrupt cardiogenic shock with or without dysrhythmia. This study evaluated the impact of extracorporeal membrane oxygenation (ECMO) on AFM-related hemodynamic compromise dysrhythmias. We also reported the clinical experience of AFM at our hospital.
View Article and Find Full Text PDFBackground: This study aimed to investigate intima-media thickness (IMT) of the common carotid arteries in children with acute Kawasaki disease (KD).
Methods: Between 2009 and 2011, patients fulfilling the criteria for KD, including a fever lasting >5 days, were prospectively enrolled in this study. Laboratory data, echocardiography, and IMT were measured and compared with matched controls.
Nitric oxide (NO) deficiency mediates oxidative stress in the kidney and is involved in the development of hypertension. NO synthesis occurs via 2 pathways: nitric oxide synthase (NOS) dependent and NOS-independent. We tested whether the development of hypertension is prevented by restoration of NO by dietary l-citrulline or nitrate supplementation in young spontaneously hypertensive rats (SHRs).
View Article and Find Full Text PDFArticle Synopsis
- Nitric oxide deficiency links to hypertension, with previous studies indicating neuronal nitric oxide synthase (nNOS) plays a significant role in hypertension and kidney damage in hypertensive rats.
- In this study, increasing the protein inhibitor of nNOS (PIN) in the kidneys was tested for its effects on hypertension, using small interfering RNA (siRNA) to target PIN as a potential treatment.
- Results showed that siRNA targeting PIN effectively reduced blood pressure increases in hypertensive rats and decreased PIN expression, hinting that PIN is a key factor in the development of hypertension.
Predictors for Regression of Large Secundum Atrial Septal Defects Diagnosed in Infancy.
Acta Cardiol Sin
January 2013
Pupose: To determine predictive factors of spontaneous closure or size reduction in large secundum-type atrial septal defects (ASD) diagnosed in infancy prior to catheterization or surgical intervention.
Methods: From June 2003 to October 2009, 59 infants diagnosed with secundum-type ASDs measuring ≥ 8 mm in the first year of life were retrospectively enrolled. We reviewed medical records, as well as electrocardiography and echocardiography findings.
Background: Free tissue transfer in patients with organic mental disorder has always been known to be risky. Herein, the outcomes of free tissue transfers for head and neck reconstruction in those with alcohol-induced mental disorder were analyzed.
Materials And Methods: We retrospectively reviewed and analyzed data from the past 10 years of 1,364 patients who had undergone microsurgical tissue transfers after head and neck cancer ablation.