Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Perfluoroalkyl acids (PFAAs) are a group of common chemicals that ubiquitously exist in wildlife and humans. Experimental data suggest that they may alter T-lymphocyte functioning in situ by preferentially enhancing the development of T-helper 2 (TH2)- and inhibiting TH1-lymphocyte development and might increase allergic inflammation, but few human studies have been conducted. To evaluate the association between serum PFAAs concentrations and T-lymphocyte-related immunological markers of asthma in children, and further to assess whether gender modified this association, 231 asthmatic children and 225 non-asthmatic control children from Northern Taiwan were recruited into the Genetic and Biomarker study for Childhood Asthma. Serum concentrations of ten PFAAs and levels of TH1 [interferon (IFN)-γ, interleukin (IL)-2] and TH2 (IL-4 and IL-5) cytokines were measured. The results showed that asthmatics had significantly higher serum PFAAs concentrations compared with the healthy controls. When stratified by gender, a greater number of significant associations between PFAAs and asthma outcomes were found in males than in females. Among males, adjusted odds ratios for asthma among those with the highest versus lowest quartile of PFAAs exposure ranged from 2.59 (95% CI: 1.14, 5.87) for the perfluorobutanesulfonate (PFBS) to 4.38 (95% CI: 2.02, 9.50) for perfluorooctanesulfonate (PFOS); and serum PFAAs were associated positively with TH2 cytokines and inversely with TH1 cytokines among male asthmatics. Among females, no significant associations between PFAAs and TH2 cytokines could be detected. In conclusion, increased serum PFAAs levels may promote TH cell dysregulation and alter the availability of key TH1 and TH2 cytokines, ultimately contributing to the development of asthma that may differentially impact males to a greater degree than females. These results have potential relevance in asthma prevention.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.scitotenv.2016.03.187 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Distinct binding affinity of perfluoroalkyl acids to plant and animal proteins revealed by dialysis experiments, fluorescence spectroscopy, and QSAR modeling.
Ecotoxicol Environ Saf
February 2025
MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China. Electronic address:
Understanding the binding dynamics between perfluoroalkyl acids (PFAAs) and proteins is crucial for risk assessment, as protein binding plays a vital role in the bioaccumulation of PFAAs. This study employed dialysis experiments to measure the protein-water partition coefficient of PFAAs with representative plant and animal proteins, including standard bovine serum albumin, soy protein isolate, and C-phycocyanin. Fluorescence spectroscopy was investigated to elucidate the binding affinity of PFAAs on bovine serum albumin (BSA).
View Article and Find Full Text PDFEnvironmental Occurrence and Biotic Concentrations of Ultrashort-Chain Perfluoroalkyl Acids: Overlooked Global Organofluorine Contaminants.
Environ Sci Technol
December 2024
Department of Civil and Environmental Engineering, Colorado School of Mines, Golden, Colorado 80401, United States.
Article Synopsis
- PFASs are a group of man-made chemicals, and ultrashort-chain PFAAs have become a focus due to their environmental impact and prevalence.
- A literature database from 1990 to 2024 reveals that these ultrashort-chain PFAAs, particularly TFA, are widely found in various environments and often at higher concentrations than longer-chain PFASs.
- The review also indicates that ultrashort-chain PFAAs are present in many living organisms, including humans, and emphasizes the need for research and regulation due to their increasing significance in environmental health discussions.
Benchmark Dose for Dioxin Based on Gestational Diabetes Mellitus Using Coexposure Statistical Methods and an Optimized Physiologically Based Toxicokinetic Model.
Environ Health (Wash)
September 2024
NHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit (No. 2019RU014), China National Center for Food Safety Risk Assessment, Beijing 100021, China.
Article Synopsis
- Dioxins, known endocrine disruptors, were studied for their link to gestational diabetes mellitus (GDM) in a controlled group of 77 GDM cases and 154 controls, measuring various chemical compounds in early pregnancy.
- Advanced statistical methods like Bayesian machine kernel regression were used to identify significant chemicals and calculate benchmark doses (BMD) of dioxins, revealing that higher levels of total dioxin exposure significantly increase GDM risk.
- The research determined that the daily dietary exposure threshold for dioxins should stay below 4.34 pg TEQ per kg body weight per week to minimize health risks.
Relationship Between Perfluoroalkyl Acids in Human Serum and Sjogren's Syndrome: A Case-Control Study of Populations in Hangzhou, China.
Toxics
October 2024
Department of Rheumatology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou 310009, China.
Exposure to perfluoroalkyl acids (PFAAs) has been found to elicit a range of detrimental effects on human health. However, limited research has investigated the impact of PFAAs on immunity and immune disorders such as Sjogren's syndrome, with existing studies yielding inconsistent results. This study was conducted in Hangzhou, China, with an initial cohort comprising 156 healthy individuals and 162 patients diagnosed with Sjogren's syndrome.
View Article and Find Full Text PDFCross-cutting studies of per- and polyfluorinated alkyl substances (PFAS) in Arctic wildlife and humans.
Sci Total Environ
December 2024
The National Hospital of the Faroe Islands, Department of Research, Sigmundargøta 5, FO-100 Torshavn, The Faroe Islands; University of the Faroe Islands, Center of Health Science, Torshavn, The Faroe Islands. Electronic address:
This cross-cutting review focuses on the presence and impacts of per- and polyfluoroalkyl substances (PFAS) in the Arctic. Several PFAS undergo long-range transport via atmospheric (volatile polyfluorinated compounds) and oceanic pathways (perfluorinated alkyl acids, PFAAs), causing widespread contamination of the Arctic. Beyond targeting a few well-known PFAS, applying sum parameters, suspect and non-targeted screening are promising approaches to elucidate predominant sources, transport, and pathways of PFAS in the Arctic environment, wildlife, and humans, and establish their time-trends.
View Article and Find Full Text PDF