The Impact of Perfluoroalkyl Substances on the Clinical Manifestations of Primary Sjögren Syndrome.

Sjogren's syndrome is an autoimmune disease that may be triggered by environmental factors. While the impact of perfluoroalkyl substances (PFASs) on the human immune system has been investigated, their specific effect on Sjogren's syndrome remains unreported. We conducted this study to evaluate the association between PFAS exposure and clinical manifestations of pSS.

Relationship Between Perfluoroalkyl Acids in Human Serum and Sjogren's Syndrome: A Case-Control Study of Populations in Hangzhou, China.

Exposure to perfluoroalkyl acids (PFAAs) has been found to elicit a range of detrimental effects on human health. However, limited research has investigated the impact of PFAAs on immunity and immune disorders such as Sjogren's syndrome, with existing studies yielding inconsistent results. This study was conducted in Hangzhou, China, with an initial cohort comprising 156 healthy individuals and 162 patients diagnosed with Sjogren's syndrome.

Association of serum bisphenols, parabens, and triclosan concentrations with Sjögren Syndrome in the Hangzhou, China population.

Exposure to endocrine-disrupting chemicals (EDCs) has been linked to various immune deficiency disorders, including autoimmune diseases like Sjögren Syndrome (SjS). However, the detrimental effects of exposure to EDCs, including bisphenols, parabens, and triclosan (TCS), on SjS have been inadequately documented. Thus, we conducted a cross-sectional study that included both healthy individuals (controls) and patients with SjS (cases).

Organophosphate esters concentrations in human serum and their associations with Sjögren syndrome.

Organophosphate esters (OPEs) are widely used as flame retardants and plasticizers due to their excellent properties. The interference of OPEs on immune function has been proven, but the epidemiological data on OPEs exposure to related immune function diseases, such as sjögren syndrome (SjS), is limited. In cross-sectional study, 283 serum samples were collected from healthy individuals (n = 145) and patients with SjS (n = 138) in Hangzhou, China.