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Cellular contractility, driven by actomyosin networks coupled to cadherin cell-cell adhesion junctions, is a major determinant of cellular rearrangement during morphogenesis. It now emerges that contractility arises as the emergent property of a mechanochemical feedback system that encompasses the signals that regulate contractility and the elements of the actomyosin network itself.
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http://dx.doi.org/10.1016/bs.ctdb.2015.10.021 | DOI Listing |
Nat Commun
September 2025
Theoretical and Computational Systems Biology Program, Institute for Integrative Systems Biology (I2SysBio), CSIC-UV, Paterna, Spain.
Bacteria often encounter physico-chemical stresses that disrupt division, leading to filamentation, where cells elongate without dividing. Although this adaptive response improves survival, it also exposes filaments to significant mechanical strain, raising questions about the mechanochemical feedback in bacterial systems. In this study, we investigate how mechanical strain modifies the geometry of bacterial filaments and influences the Min oscillatory system, a reaction-diffusion network central to division in Escherichia coli.
View Article and Find Full Text PDFDev Cell
August 2025
The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address:
How simple tissue primordia sculpt complex functional organs, robustly and reproducibly, remains elusive. During zebrafish development, the embryonic myocardial wall matures into an intricate 3D architecture, composed of an outer compact layer enveloping an inner layer of multicellular trabecular ridges. How these tissue layers acquire their characteristic form suited for their function remains an open question.
View Article and Find Full Text PDFBiomimetics (Basel)
July 2025
Department of Physics and Astronomy, Tufts University, Medford, MA 02155, USA.
Despite significant advances in understanding neuronal development, a fully quantitative framework that integrates intracellular mechanisms with environmental cues during axonal growth remains incomplete. Here, we present a unified biophysical model that captures key mechanochemical processes governing axonal extension on micropatterned substrates. In these environments, axons preferentially align with the pattern direction, form bundles, and advance at constant speed.
View Article and Find Full Text PDFBiochem Soc Trans
July 2025
Division of Molecular Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Gastrulation is an essential process in the early embryonic development of all higher animals. During gastrulation, the three embryonic germ layers, the ectoderm, mesoderm and endoderm, form and move to their correct positions in the developing embryo. This process requires the integration of cell division, differentiation and movement of thousands of cells.
View Article and Find Full Text PDFCancer Med
July 2025
Department of Pharmacology and Toxicology, School of Basic Medical Sciences, Xi'an Medical University, Xi'an, China.
Background: Emerging evidence implicates mechanotransduction pathways in modulating bladder carcinoma (BLCA) pathogenesis. However, the crosstalk between Piezo1 and integrin β1 (ITGB1) in extracellular matrix (ECM) stiffness-driven tumorigenesis remains a critical knowledge gap. This study systematically investigates the functional synergy of Piezo1/ITGB1 in orchestrating ECM biomechanical remodeling to fuel BLCA progression.
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