Article Synopsis
- Magneto is a new, single-component actuator that combines a cation channel with a magnetically sensitive protein, allowing for noninvasive control of neuronal activity.
- This tool overcomes limitations of traditional optogenetic and chemogenetic methods, such as their invasive nature and slow activation times, validated through various assays including in vitro calcium imaging and in vivo recordings.
- The effectiveness of Magneto was demonstrated by its ability to influence reward behavior through striatal dopamine receptor 1 neurons in mice, showcasing its potential for studying complex animal behaviors.
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Article Abstract
Optogenetic and chemogenetic actuators are critical for deconstructing the neural correlates of behavior. However, these tools have several limitations, including invasive modes of stimulation or slow on/off kinetics. We have overcome these disadvantages by synthesizing a single-component, magnetically sensitive actuator, "Magneto," comprising the cation channel TRPV4 fused to the paramagnetic protein ferritin. We validated noninvasive magnetic control over neuronal activity by demonstrating remote stimulation of cells using in vitro calcium imaging assays, electrophysiological recordings in brain slices, in vivo electrophysiological recordings in the brains of freely moving mice, and behavioral outputs in zebrafish and mice. As proof of concept, we used Magneto to delineate a causal role of striatal dopamine receptor 1 neurons in mediating reward behavior in mice. Together our results present Magneto as an actuator capable of remotely controlling circuits associated with complex animal behaviors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846560 | PMC |
| http://dx.doi.org/10.1038/nn.4265 | DOI Listing |
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