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http://dx.doi.org/10.1016/j.prp.2015.08.011 | DOI Listing |
Environ Geochem Health
September 2025
Policy Research Center for Environment and Economy, Ministry of Ecology and Environment of the People's Republic of China, Beijing, 100101, China.
The behavior of polycyclic aromatic hydrocarbons (PAHs) released from tire road wear particles (TRWPs) in human digestive fluids may pose a significant risk to human health. However, the current understanding of the release pattern and influencing factors of PAHs from TRWPs is still insufficient. In this study, the release characteristics of PAHs from UV-aging TRWPs (ATRWPs) were systematically investigated by in vitro digestive simulation experiments, release kinetic model fitting and control variable experiments.
View Article and Find Full Text PDFMol Pharm
September 2025
Johnson & Johnson, Translational PK/PD & Investigational Toxicology, Spring House, Pennsylvania 19002, United States.
Human intestinal permeability is a key determinant of the oral fraction absorbed () of active pharmaceutical ingredients (APIs). This study evaluated the ability of an in-house canine Mdr1 (cMdr1) knockout (KO) Madin-Darby Canine Kidney (MDCK) cell line to correlate apparent permeability () with human small intestinal permeability (). values of 16 reference compounds with high, medium, or low permeabilities were measured in the in-house cMdr1 KO MDCK protocol under pH gradient (6.
View Article and Find Full Text PDFJ Robot Surg
September 2025
Department of Oncology, Shengli Oilfield Central Hospital, Dongying, China.
A major cause of cancer death, colorectal cancer is becoming more common in younger people. The comparative effectiveness of robotic versus laparoscopic total mesorectal excision (TME) as surgical interventions for mid-low rectal cancer following neoadjuvant chemoradiotherapy (nCRT) remains uncertain. To systematically evaluate oncological, perioperative, and survival outcomes of robotic versus laparoscopic surgery for mid-low rectal cancer following nCRT.
View Article and Find Full Text PDFJ Adv Res
September 2025
National Medical Products Administration (NMPA) Key Laboratory for Safety Evaluation of Cosmetics, Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Toxicology, School of Public Health, Southern Medical University, Guangzhou, China. Electronic address: huangzhenlie85825
Introduction: The increasing use of biodegradable plastics has led to the inevitable human consumption of biodegradable microplastics (MPs). These MPs can be degraded and absorbed into various organs and tissues via the gastrointestinal tract, with the liver being the primary target for digestion and absorption.
Objectives: This study aimed to investigate the toxic effects and mechanisms of biodegradable MPs on the liver following gastrointestinal degradation.
Int J Biol Macromol
September 2025
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Jiangsu Provincial Key Laboratory of Functional Substances in Traditional C
The immune system is the ultimate defense against diseases and its dysregulated homeostasis greatly threatens human health. Natural polysaccharides have a variety of biological activities and show promising applications in immunomodulation. In this study, we characterized the structure of the polysaccharide IRPS-TE-3 from Isatidis Radix using morphological analysis, molecular weight analysis, monosaccharide composition analysis, methylation analysis and nuclear magnetic resonance spectroscopy.
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