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Studies on Intervention Process Evaluation are attracting growing attention in the literature on interventions linked to stress and the wellbeing of workers. There is evidence that some elements relating to the process and content of an intervention may have a decisive role in implementing it by facilitating or hindering the effectiveness of the results. This study aimed to provide a process evaluation on interventions to assess and manage risks related to work-related stress using a methodological path offered by INAIL. The final sample is composed of 124 companies participating to an interview on aspects relating to each phase of the INAIL methodological path put in place to implement the intervention. INAIL methodology has been defined as useful in the process of assessing and managing the risks related to work-related stress. Some factors related to the process (e.g., implementation of a preliminary phase, workers' involvement, and use of external consultants) showed a role in significant differences that emerged in the levels of risk, particularly in relation to findings from the preliminary assessment. Main findings provide information on the key aspects of process and content that are useful in implementing an intervention for assessing and managing risks related to work-related stress.
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http://dx.doi.org/10.1155/2015/197156 | DOI Listing |
Clin Epigenetics
September 2025
Department of Psychiatry and Psychotherapy, Philipps University Marburg, Marburg, Germany.
Background: Work-related stress is a well-established contributor to mental health decline, particularly in the context of burnout, a state of prolonged exhaustion. Epigenetic clocks, which estimate biological age based on DNA methylation (DNAm) patterns, have been proposed as potential biomarkers of chronic stress and its impact on biological aging and health. However, their role in mediating the relationship between work-related stress, physiological stress markers, and burnout remains unclear.
View Article and Find Full Text PDFBMC Public Health
September 2025
Department of Sociology and Work Science, University of Gothenburg, Gothenburg, Sweden.
Background: Mental health problems are common in the working-age population. More knowledge is needed on how to support work participation and reduce sickness absence. The objective of the study was to estimate the distribution of mental well-being and work capacity in women and men in a working population and assess the association between mental well-being and work capacity, while adjusting for sociodemographic characteristics, health status, and working positions.
View Article and Find Full Text PDFMol Psychiatry
September 2025
Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, USA.
Dysregulated dopaminergic signaling has been implicated in the pathophysiology of major depressive disorder (MDD) and childhood sexual abuse (CSA), but inconsistencies abound. In a multimodal PET-functional MRI study, harnessing the highly selective tracer [C]altropane, we investigated dopamine transporter availability (DAT) and resting-state functional connectivity (rsFC) within reward-related regions among 112 unmedicated individuals (MDD: n = 37, MDD/CSA: n = 18; CSA no MDD: n = 14; controls: n = 43). Striatal DAT and seed-based rsFC were assessed in the dorsal and ventral striatum and the ventral tegmental area.
View Article and Find Full Text PDFPlant Physiol Biochem
August 2025
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China. Electronic address:
The PR10 (Pathogenesis-Related Protein 10) family plays a crucial role in plant defense and growth regulation, with unique hydrophobic cavities that bind various ligands, including phytohormones and alkaloids. Among them, Norcoclaurine Synthases (NCS) are key enzymes in benzylisoquinoline alkaloid (BIAs) biosynthesis, catalyzing the Pictet-Spengler reaction to form the precursor (S)-norcoclaurine. However, the evolutionary origins and functions of the PR10 family in BIA biosynthesis remain unclear.
View Article and Find Full Text PDFJ Voice
September 2025
Department of Speech-Language-Hearing Sciences, Medical School, Federal University of Minas Gerais - UFMG, Belo Horizonte, Minas Gerais, Brazil. Electronic address:
Objective: To analyze the association between the risk of voice disorders and sociodemographic, work, and general health factors in urban and rural school teachers.
Methods: This is an observational, cross-sectional, analytical study with 1705 teachers from urban schools and 202 from rural schools teaching elementary and high school in Minas Gerais, Brazil. The exclusion criteria were being retired or no longer teaching and/or not accepting to participate in the study.