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Objectives: We evaluated organization- and network-level factors that influence organizations' perceived success. This is important for managing interorganizational networks, which can mobilize communities to address complex health issues such as physical activity, and for achieving change.
Methods: In 2011, we used structured interview and network survey data from 22 states in the United States to estimate multilevel random-intercept models to understand organization- and network-level factors that explain perceived network success.
Results: A total of 53 of 59 "whole networks" met the criteria for inclusion in the analysis (89.8%). Coordinators identified 559 organizations, with 3 to 12 organizations from each network taking the online survey (response rate = 69.7%; range = 33%-100%). Occupying a leadership position (P < .01), the amount of time with the network (P < .05), and support from community leaders (P < .05) emerged as correlates of perceived success.
Conclusions: Organizations' perceptions of success can influence decisions about continuing involvement and investment in networks designed to promote environment and policy change for active living. Understanding these factors can help leaders manage complex networks that involve diverse memberships, varied interests, and competing community-level priorities.
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http://dx.doi.org/10.2105/AJPH.2015.302828 | DOI Listing |
J Neurosci
September 2025
Department of Neurology, F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
The proper development of excitatory/inhibitory balance is critical for brain function, as any imbalance has been associated with myriad neuropsychiatric disorders. How this balance evolves during synaptic development remains unclear. To address this question, we examine how manipulations of SIRPα, a cell-adhesion molecule that organizes excitatory synaptic development in the hippocampus, affect inhibitory synaptogenesis to maintain excitatory/inhibitory balance, using mice of either sex.
View Article and Find Full Text PDFSci Rep
September 2025
Network & Cognitive Neuroscience Lab, Centre for Brain Science & Applications, School of Artificial Intelligence & Data Science, Indian Institute of Technology Jodhpur, Jodhpur, India.
Local segregation and global integration are the fundamnetal organizational principles of human brain. It is unknown how subcortex configures itself with respect to the segregation and integration dynamics at rest. Using resting state functional MRI data of 92 healthy adult participants, we revealed three non-overlapping segregated communities in subcortex, confining anatomically to thalamus, basal ganglia, and subcortical limbic structures, termed as subcortical networks.
View Article and Find Full Text PDFBiomedicines
August 2025
Medical Section, Romanian Academy, 010071 Bucharest, Romania.
Neurodegeneration is increasingly recognized not as a linear trajectory of protein accumulation, but as a multidimensional collapse of biological organization-spanning intracellular signaling, transcriptional identity, proteostatic integrity, organelle communication, and network-level computation. This review intends to synthesize emerging frameworks that reposition neurodegenerative diseases (ND) as progressive breakdowns of interpretive cellular logic, rather than mere terminal consequences of protein aggregation or synaptic attrition. The discussion aims to provide a detailed mapping of how critical signaling pathways-including PI3K-AKT-mTOR, MAPK, Wnt/β-catenin, and integrated stress response cascades-undergo spatial and temporal disintegration.
View Article and Find Full Text PDFCurr Alzheimer Res
August 2025
Department of Psychology, University of Freiburg, Freiburg, Germany.
Introduction: Alzheimer's disease is a progressive neurodegenerative condition characterized by the gradual deterioration of cognitive functions. Early identification of functional brain changes is crucial for timely diagnosis and effective intervention. This study employs multiplex network analysis to examine alterations in brain connectivity topology associated with Alzheimer's Disease, to identify early biomarkers and uncover potential therapeutic targets.
View Article and Find Full Text PDFCortex
August 2025
Univ. Grenoble Alpes, CNRS, LPNC, Grenoble, 38000, France. Electronic address:
Hemispherotomy, a neurosurgical procedure that functionally disconnects the affected hemisphere, is the recommended curative treatment for Rasmussen's encephalitis. Following a typically normal developmental period, individuals with Rasmussen's encephalitis develop progressive hemispheric dysfunction and severe epilepsy, ultimately resulting in exclusive "mono-hemispheric" functioning after hemispherotomy. The aim of this study was to provide an in-depth assessment of long-term cognitive outcomes in Rasmussen's encephalitis patients, several years after hemispherotomy.
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