98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343061 | PMC |
http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2015.06.018 | DOI Listing |
Background: Addictive disorders remain a global problem, affecting health, society and the economy. The etiopathogenesis of addictions, which have a multifactorial nature, is poorly understood, making it difficult to develop personalized treatment approaches. Of particular interest is the gene, which regulates serotonergic transmission.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
September 2025
The University of Leicester Ulverscroft Eye Unit, School of Psychology and Vision Sciences, University of Leicester, Leicester, United Kingdom.
Purpose: To define the genetic architecture of foveal morphology and explore its relevance to foveal hypoplasia (FH), a hallmark of developmental macular disorders.
Methods: We applied deep-learning algorithms to quantify foveal pit depth from central optical coherence tomography (OCT) B-scans in 61,269 UK Biobank participants. A genome-wide association study (GWAS) was conducted using REGENIE, adjusting for age, sex, height, and ancestry.
Medicine (Baltimore)
September 2025
Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Wulumuqi, Xinjiang Uygur Autonomous Region, The People's Republic of China.
The Xinjiang Uygur Autonomous Region of China is characterized by unique genetic and environmental factors, influenced by its geography, culture, and interethnic interactions. Understanding lipid metabolism in this population may help identify novel genetic regulators relevant to cardiovascular risk. An extreme phenotype sequencing strategy was applied to Han Chinese university students from Xinjiang.
View Article and Find Full Text PDFClin Exp Dermatol
September 2025
Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Intravascular large B-cell lymphoma (IVLBCL) is a rare extranodal lymphoma characterized by selective growth of neoplastic lymphocytes within small vessels, and often lacking lymphadenopathy or circulating malignant cells. Its clinical heterogeneity and nonspecific symptoms frequently cause delayed diagnosis and treatment. We report 3 new cases in elderly patients presenting with unexplained anemia, systemic symptoms in 2 patients, and purpuric skin lesions in one patient.
View Article and Find Full Text PDFPLoS One
September 2025
People's Hospital of Ningxia Hui Autonomous Region, Ningxia Eye Hospital, Yinchuan, China.
Purpose: To investigate the variants in 18 disease-causing genes associated with nonsyndromic myopia in 83 Chinese individuals diagnosed with early-onset high myopia(eo-HM).
Methods: Variants in 18 candidate genes in 83 probands with eo-HM were distinguished by whole-exome sequencing (WES) and assessed by multistep bioinformatics analysis.
Results: Four likely pathogenic variants were detected in 4 of the 83 probands (4.