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http://dx.doi.org/10.3389/fimmu.2015.00090 | DOI Listing |
Paediatr Child Health
August 2025
Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Every paediatrician's career includes the provision of care for children with life-limiting conditions. The College of Physicians and Surgeons of Ontario published a revised policy, "Decision-making for End-of-Life Care," in March 2023; in this commentary we explore the ramifications of this policy for community and acute care paediatricians in Ontario and highlight principles to contextualize this beyond provincial borders. In particular we discuss its impact upon clinicians' moral distress and the importance of: i) early and longitudinal engagement with patients and families, where possible, to contextualize the role of resuscitative measures (if any) in addition to the many other important considerations concerning high quality end-of-life care; and ii) preventing bias and calibrating decision-making with clinical colleagues (including Bioethics) to ensure CPR is never withheld because of a child's such as their race, age, or disability.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Protein Research Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab, Alexandria, 21934, Egypt. Electronic address:
The growing demand for sustainable agriculture imposes innovative biocontrol strategies to mitigate phytopathogen threats while reducing dependence on chemical pesticides. This review explores the current knowledge on enzyme-based biocontrol, focusing on hydrolytic enzymes (e.g.
View Article and Find Full Text PDFImmunol Rev
September 2025
Laboratory of Barrier Immunity, Division of Molecular Hematology, Department of Laboratory Medicine, Faculty of Medicine, Lund University, Lund, Sweden.
The skin is the outermost organ that serves as the host's live, microbiota-inhabited physical border, evolved to cope with continuous confrontation by a wide variety of environmental elements. This dynamic borderline is prone to injury and damage. Therefore, to deliver on the critical demands for protection, skin is tightly associated with innate and adaptive defense mechanisms that ensure homeostatic tissue barrier integrity.
View Article and Find Full Text PDFJ Environ Manage
September 2025
Agronomical Engineering Department, Technical University of Cartagena (UPCT), 30202, Cartagena, Spain. Electronic address:
River systems, besides shaping their landscapes through the formation of Fluvisols, can also act as pathways for transporting significant pollutants, affecting both the river and its surrounding areas. One such pollutant is mercury (Hg). To assess the impact on sediments and adjacent riverbanks, including Fluvisols and their vegetation, the alluvial plains near Poland's most important river have been studied to understand this process and propose effective management measures.
View Article and Find Full Text PDFBiology (Basel)
July 2025
Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM 88003, USA.
Proto-oncogenes in the superfamily play dual roles in maintaining cellular homeostasis, such as regulating growth signals and contributing to cancer development through proliferation and deregulation. Activating proto-oncogenes in vitro transforms cells, underscoring their centrality in gene regulation and cellular networks. Despite decades of research, poor outcomes in advanced cancers reveal gaps in understanding Ras-driven mechanisms or therapeutic strategies.
View Article and Find Full Text PDF