Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Mean platelet volume (MPV) is generally accepted as a new marker of cardiovascular disease risk in several studies.
Objectives: This study aimed to determine the association of MPV with androgen hormones and insulin resistance (IR) in nonobese patients with polycystic ovary syndrome (PCOS).
Patients And Methods: A total of 136 patients with newly diagnosed reproductive-age PCOS (regarding the criteria of new PCOS phenotypes, based on the Rotterdam criteria) who were nonobese with the mean age of 25 years (25.39 ± 5.51) and mean body mass index (BMI) of 21 kg/m(2) (22.07 ± 2.13) were included. In addition, 59 healthy subjects with mean age of 26 years (22.07 ± 2.13) and mean BMI of 22 kg/m(2) (21.52 ± 3.84) were recruited as control. Total blood count (including MPV), total testosterone, free testosterone, dehydroepiandrosterone-sulfate (DHEAS), and androstenedione levels were recorded. IR was calculated from blood chemistry measurements of fasting insulin and glucose according to updated homeostasis model assessment.
Results: No differences were observed in mean MPV values between patients and control group (9.02 fL (8.5-10.1) and 8.9 fL (7.7-9.1), respectively; P = 0.777). MPV values were similar among nonobese patients with and without IR and control subjects (P > 0.05). We detected significantly lower values of MPV in patients with hyperandrogenemia in comparison to patients with normal androgen levels (8.7 and 9.5 fL, P = 0.012). There was a negative correlation between total testosterone, DHEAS, and MPV (P = 0.016, r = -0.229; and P = 0.006, r = -0.261, respectively). Multiple logistic regression analyses confirmed the independence of these associations.
Conclusions: Our study revealed that nonobese women with and without PCOS have similar MPV values. While IR does not have any effect on MPV, elevated androgen levels are associated with a low MPV in nonobese patients with PCOS.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338650 | PMC |
| http://dx.doi.org/10.5812/ijem.18642 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of Metabolically Healthy and Unhealthy Obesity on Outcomes of Sepsis Complicated by Septic Shock in Elderly Patients.
J Intensive Care Med
September 2025
Independent Researcher, Outcomes Research, Atlanta, GA, USA.
Purpose: Obesity is a risk factor for sepsis complications in older adults. We assessed the impact of metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO) on outcomes in septic shock.
Methods: We conducted a retrospective analysis using the National Inpatient Sample (2016-2020) to identify a cohort of 1,737,075 patients aged 65 years and older who were hospitalized with septic shock, as defined by ICD-10 diagnosis codes.
A machine learning model for predicting obesity risk in patients with diabetes mellitus: analysis of NHANES 2007-2018.
Front Public Health
September 2025
Department of Plastic and Reconstructive Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region & Research Center of Medical Sciences, Guangxi Academy of Medical Sciences, Nanning, Guangxi, China.
Background: Obesity is a prevalent and clinically significant complication among individuals with diabetes mellitus (DM), contributing to increased cardiovascular risk, metabolic burden, and reduced quality of life. Despite its high prevalence, the risk factors for obesity within this population remain incompletely understood. With the growing availability of large-scale health datasets and advancements in machine learning, there is an opportunity to improve risk stratification.
View Article and Find Full Text PDFMulti-Center Health Informatics to Examine the Implementation of Guideline-Directed Medical Therapy in Chronic Kidney Disease.
J Prim Care Community Health
September 2025
Division of Nephrology, Department of Medicine, National University Hospital, Singapore.
Background: Chronic kidney disease (CKD) management was largely centered around renin-angiotensin-aldosterone system inhibitors (RAASi) optimization, until recent emergence of novel therapeutics. However, slow adoption of guideline-directed therapy leaves patients vulnerable to disease progression. In 2022, a data-driven informatics approach was introduced to track real-time adherence to best practices.
View Article and Find Full Text PDFImpact of obesity on surgical outcomes for robotic‑assisted transvaginal natural orifice transluminal endoscopic surgery (RA-vNOTES) hysterectomy.
Eur J Obstet Gynecol Reprod Biol
September 2025
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA; Division of Minimally Invasive Gynecologic Surgery, Baylor College of Medicine, Houston, TX, USA. Electronic address:
Objective: To investigate the impact of obesity on surgical outcomes following robotic-assisted transvaginal natural orifice transluminal endoscopic surgery (RA-vNOTES) for hysterectomy.
Design: Retrospective cohort.
Setting: Single academic tertiary care hospital in Houston, Texas, USA.
Feasibility and outcomes of the direct anterior approach in total hip arthroplasty for obese patients: a systematic review.
Musculoskelet Surg
September 2025
Chief of Dipartimento Osteoarticolare, AUSL della Romagna, Ravenna, Italy.
Total hip arthroplasty (THA) via the direct anterior approach (DAA) is a preferred surgical technique due to its benefits, including reduced soft tissue disruption and faster recovery. However, obesity, defined as a body mass index (BMI) ≥ 30 kg/m, poses unique challenges in DAA-THA, increasing the risk of complications and technical difficulties. This systematic review aims to assess the clinical and functional outcomes, complication rates, and reoperation rates in obese patients undergoing DAA-THA compared to non-obese patients.
View Article and Find Full Text PDF