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We present the research advances on the development of 50-200 mJ energy range diode-pumped Yb:CaF2- based multipass amplifiers operating at relatively high repetition rates. These laser amplifiers are based on diverse innovative geometries. All these innovations aim to design compact, stable and reliable amplifiers adapted to our application that consists in pumping ultrashort-pulse OPCPA (optical parametric chirped pulse amplifier) systems in the frame of the Apollon 10 PW laser project. The targeted repetition rate is in the range of 20-100 Hz with energies of few tens of mJ for the first stages up to 1 J for the final stage. An analysis of the specificities of Yb:CaF2 is done to explain the different options we chose to fulfil these specifications. The critical points and limitations of the multipass Yb:CaF2-based amplifiers are subsequently discussed. To overcome the encountered problems, different issues are investigated such as crystal optimisation, laser head geometry, thermo-optical dynamics or coherent combining techniques. Experimental results for different multipass configurations are demonstrated and discussed.
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http://dx.doi.org/10.1109/TOH.2014.2330619 | DOI Listing |
PLoS One
September 2025
Emergency Department, Peking University Third Hospital, Beijing, China.
Introduction: Triage is an essential strategy to mitigate crowding and guarantee patients' safety in emergency departments. To improve the quality of triage in emergency departments, Nurses should be equipped with the necessary competencies. Therefore, this review aims to synthesize available evidence on the competency elements required for triage nurses in emergency departments and to identify factors that influence their competency development.
View Article and Find Full Text PDFIEEE Trans Pattern Anal Mach Intell
September 2025
Stochastic Kriging (SK) is a generalized variant of Gaussian process regression, and it is developed for dealing with non-i.i.d.
View Article and Find Full Text PDFActa Parasitol
September 2025
Région du Centre, Université Joseph Ki-Zerbo, Rue Thomas Sankara, O3 BP 7021, Ouagadougou, Burkina Faso.
Introduction: The objective of the World Health Organization is to achieve the interruption of human African trypanosomiasis (HAT) transmission by 2030.
Methods: This review aims to update knowledge on HAT, through a synthesis on the epidemiology, diagnostic tools and drugs of HAT.
Results: From 1960 to 2024 approximately 132,063 cases of HAT have been reported across Africa.
Clin Rheumatol
September 2025
Department of Dermatology, the First Affiliated Hospital, Army Medical University, No. 29 Gaotanyan Street, Shapingba District, Chongqing, China.
Background: Plasmacytoid dendritic cells (pDCs) are a specialized subset of dendritic cells known for their ability to produce type I interferon (IFN I), contributing to antiviral defense and the pathogenesis of autoimmune diseases like systemic lupus erythematosus (SLE). In SLE patients, pDCs are excessively activated, leading to overproduction of IFN-α, which plays a critical role in disease progression. However, no bibliometric analysis has been conducted on the relationship between pDCs and SLE.
View Article and Find Full Text PDFDevelopment
September 2025
MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.
In an era of expanding reproductive possibilities, the human embryo has come to represent both immense potential and profound constraint. Advances in medically assisted reproduction (MAR) have led to the cryopreservation of hundreds of thousands of embryos each year, yet many remain unused and are ultimately discarded. Meanwhile, studies aimed at understanding infertility, early human development and preventing miscarriage continue to face significant barriers, with only a small fraction of embryos ever donated to research.
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