Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The association of rs12979860 and rs8099917 single nucleotide polymorphisms (SNPs) near IL28B with sustained virological response (SVR) in hepatic allograft recipients undergoing treatment with PEGylated interferon (PEG-IFN) plus ribavirin (RBV) for recurrent hepatitis C virus (HCV) infection remains inconclusive. We therefore performed a meta-analysis to estimate this association. A search of the literature published prior to November 1, 2013, was conducted using various databases. Eleven eligible studies were included in the meta-analysis. The pooled results revealed that rs12979860 genotype CC in the recipient, donor, and recipient/donor pair was significantly related to high SVR in the recipients (recipient: odds ratio [OR]=3.06, 95% confidence interval [CI]=2.18-4.30; donor: OR=2.65, 95% CI=1.83-3.85; recipient/donor pair: OR=6.05, 95% CI=3.16-11.58). A similar association was observed with rs8099917 genotype TT (recipient: OR=3.84, 95% CI=2.37-6.22; donor: OR=2.44, 95% CI=1.12-5.28; recipient/donor pair: OR=5.43, 95% CI=2.51-11.75). These results suggest that rs12979860 genotype CC and rs8099917 genotype TT contribute to a high SVR in the recipient after antiviral treatment.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.humimm.2014.09.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Guidelines From the French-Speaking Society of Histocompatibility and Immunogenetics for Virtual Crossmatching for Deceased Donor Kidney Transplantation and the Use of Wet Crossmatch in the Decision-Making Process.
HLA
April 2025
Laboratoire d'Immunologie et Immunogénétique, CHU de Bordeaux, Hôpital Pellegrin, Bordeaux, France.
The systematic use of Single Antigen Flow Beads assays and the implementation of high-resolution HLA typing for donors and kidney transplant recipients allow a precise identification of anti-HLA donor-specific antibodies. In France, the availability of detailed molecular biology HLA typing for deceased donors in the national organ allocation software enables anticipation of wet crossmatch results and estimation of the immunological risk for a recipient/donor pair. This key process, named virtual crossmatching, involves a thorough analysis of the recipient's anti-HLA sensitisation records.
View Article and Find Full Text PDFLiving donor uterus transplant research project in Singapore: Progress of the first case.
Acta Obstet Gynecol Scand
March 2025
Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Introduction: To report the progress of the human living uterus transplant research project in Singapore.
Material And Methods: The uterus transplant research project began in 2012 with a collaboration between the Swedish and Singapore teams. Ethics approval was obtained from the SingHealth Centralised Institutional Review Board, the SingHealth Transplant and the Singapore General Hospital Biomedical Ethics Committee to perform 5 uterus transplant procedures in a collaborative multi-site research study at the Singapore General Hospital.
Human leukocyte antigen evolutionary divergence as a novel risk factor for donor selection in acute lymphoblastic leukemia patients undergoing haploidentical hematopoietic stem cell transplantation.
Front Immunol
September 2024
Beijing BFR Gene Diagnostics Co., Ltd, Beijing, China.
Introduction: The human leukocyte antigen (HLA) evolutionary divergence (HED) reflects immunopeptidome diversity and has been shown to predict the response of tumors to immunotherapy. Its impact on allogeneic hematopoietic stem cell transplantation (HSCT) is controversial in different studies.
Methods: In this study, we retrospectively analyzed the clinical impact of class I and II HED in 225 acute lymphoblastic leukemia patients undergoing HSCT from related haploidentical donors.
DCD liver transplant in patients with a MELD over 35.
Front Immunol
September 2023
Division of Transplant Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA, United States.
Article Synopsis
- Donation after circulatory death (DCD) liver transplantation (LT) has a low occurrence in the U.S. but may provide reasonable outcomes for patients with high liver disease severity (MELD≥35).
- Analysis from UCSF and UNOS cohorts showed similar five-year survival rates between DCD and brain death donor (DBD) liver transplants, though DCD recipients experienced more complications like biliary issues and longer hospital stays.
- Factors such as younger donor age and recent transplant years improved survival rates; however, DCD grafts were identified as a risk factor in one cohort, indicating the need for careful candidate selection.
Review of interactions between high-risk pediatric heart transplant recipients and marginal donors including utilization of risk score models.
Pediatr Transplant
May 2020
Department of Cardiovascular and Thoracic Surgery, Children's Medical Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Background: Donor organ acceptance practices vary among pediatric heart transplant professionals. We sought to understand what is known about the interactions between the "high-risk" recipient and the "marginal donor," and how donor risk scores can impact this discussion.
Methods: A systematic review of published literature on pediatric HTx was undertaken with the assistance of a medical librarian.