98%
921
2 minutes
20
Objective: This study aimed to classify sequential swallowing types using videoendoscopy (VE) avoiding radiation exposure and compare the results using videofluoroscopy (VF).
Design: Twenty-one healthy adults simultaneously underwent VF and VE during sequential straw drinking. Each discrete swallow was classified into an L-segmental type (laryngeal vestibule opens after swallow) or L-continuous type (laryngeal vestibule closure continues after swallow) using VF and a V-segmental type (velopharynx opens after swallow) or V-continuous type (velopharynx closure continues after swallow) using VE. Test-retest reproducibility and interrater and intrarater reliability were evaluated in ten healthy adults.
Results: Of 128 swallows, 94 were L-segmental and 34 were L-continuous types as per VF, whereas 95 were V-segmental and 33 were V-continuous types as per VE. The leading edge of the bolus at swallow onset was significantly deeper in L-continuous types (P = 0.001). Laryngeal vestibule closure on VF images corresponded to velopharyngeal closure on VE images for 127 of 128 swallows (κ = 0.98, P < 0.001). All subjects showed the same types of swallows in the first and the second studies. Both interrater and intrarater reliability were high.
Conclusion: VE showed high reproducibility and reliability in the classification of sequential swallowing types.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1097/PHM.0000000000000144 | DOI Listing |
Clin Case Rep
August 2025
Department of Neurology Binzhou Medical University Hospital Binzhou Shandong P.R. China.
A 52-year-old male with T4aN0M0 floor of the mouth squamous cell carcinoma who refused surgery received sequential organ-preserving therapy: induction chemoimmunotherapy (3 cycles of tislelizumab 200 mg d1, docetaxel 75 mg/m d1, cisplatin 75 mg/m d1-3) followed by concurrent chemoradiotherapy (cisplatin 100 mg/m q21d + radiotherapy 69.96 Gy/33f). Complete clinical response was achieved.
View Article and Find Full Text PDFEClinicalMedicine
August 2025
Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
Background: Treatment deintensification, such as neoadjuvant immunochemotherapy and transoral surgery, has shown promise but remains under investigation in human papillomavirus-associated oropharyngeal squamous cell carcinoma (HPVOPSCC). We aimed to explore the efficacy and safety of neoadjuvant immunochemotherapy and the feasibility of sequential transoral surgery in patients with resectable HPVOPSCC.
Methods: In this single-arm, two-centre, phase 2 trial, patients with resectable HPVOPSCC (clinical stage T2-4N0-3M0) were recruited and received two cycles of neoadjuvant sintilimab, cisplatin, and nab-paclitaxel every three weeks, followed by transoral surgery, including transoral robotic surgery (TORS).
BMC Anesthesiol
July 2025
Department of Anesthesiology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou medical college, Hangzhou, 310014, China.
Background: This study aimed to evaluate the impact of anxiety on the pharmacodynamics of remimazolam besylate in patients undergoing gastroscopy.
Methods: Patients undergoing gastroscopy were divided into two groups: an anxiety group (Self -rating Anxiety scale, SAS ≥ 50) and a non-anxiety group (SAS < 50). All patients received intravenous administration of 5 µg/kg alfentanil combined with remimazolam besylate.
J Healthc Inform Res
September 2025
Edward S. Rogers Department of Electrical and Computer Engineering, University of Toronto, Toronto, M5S 3G4 ON Canada.
High-resolution cervical auscultation (HRCA) has emerged as a promising noninvasive method for instrumental swallowing assessment, utilizing accelerometry signals from the patient's throat during swallowing. Compared to a traditional gold standard assessment technique, such as videofluoroscopic swallowing studies, HRCA offers reduced radiation exposure risks and increased accessibility. While previous studies have demonstrated the potential of machine learning in HRCA-based swallowing kinematics assessment, the accurate tracking of anatomical landmarks has remained a challenge.
View Article and Find Full Text PDFCerebellum
July 2025
Laboratory for the Study of Upper Airway Dysfunction, Department of Biobehavioral Sciences, Teachers College, Columbia University, New York, NY, USA.
Cerebellar ataxia (CA) is a heterogenous neurodegenerative disease affecting multiple neural structures. Individuals with CA exhibit difficulty coordinating voluntary movements and have a high prevalence of cough (dystussia) and swallowing (dysphagia) dysfunction. Although skill-based approaches to cough rehabilitation are efficacious for other neurogenerative diseases, the feasibility in CA remains unexplored.
View Article and Find Full Text PDF