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We report an efficient Pd-catalyzed C(sp(2))-H activation/C-O bond formation for the synthesis of ethoxy dibenzooxaphosphorin oxides from 2-(aryl)arylphosphonic acid monoethyl esters under aerobic conditions.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077535 | PMC |
http://dx.doi.org/10.3762/bjoc.10.120 | DOI Listing |
Carbohydr Polym
November 2025
Polymer Institute of the Slovak Academy of Sciences, Dúbravská Cesta 9, 845 41 Bratislava, Slovakia; Polymer Materials Research Department, Advanced Technology and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab Ci
This study involves the synthesis of a novel 7-ethoxy-3-formyl-2-morpholino quinoline (MQ) derivative, which was hybridized with aminated chitosan (AMCH) to yield a new AMCH-MQ Schiff base. Structural characterization via H NMR, FTIR, electronic spectra, XRD, and TGA confirmed successful hybridization. Ion exchange capacity decreased from 28.
View Article and Find Full Text PDFAppl Radiat Isot
August 2025
Department of Radiology, Washington University School of Medicine, Saint Louis, Missouri, 63110, United States. Electronic address:
We report a reliable fully automated procedure to produce a promising F-18 labeled sphingosine-1-phosphate receptor 1 (S1PR1) PET ligand, 3-((2-fluoro-4-(5-(4-(2-(fluoro-F)ethoxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)benzyl) (methyl)amino)propan-1-ol ([F]FZTA) on the GE TRACERlab FX2N module, using a one-pot two-step procedure following current Good Manufacturing Practices (cGMP). The MOM-protected precursor 1 was fluorinated with no-carrier-added [F]KF, catalyzed by Kryptofix 222 under heat, to afford the intermediate [F]2. After deprotecting the MOM-group on [F]2 under acidic condition, the reaction was quenched into a neutralized solution, which was then loaded on semi-preparative HPLC for purification.
View Article and Find Full Text PDFBioorg Chem
August 2025
Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. Electronic address:
This study describes the synthesis and biological evaluation of 2-ethoxy-6-formylphenyl [1,1'-biphenyl]-4-sulfonate-based thiosemicarbazones 5(a-s) as potential inhibitors of human carbonic anhydrase isoforms hCA I and hCA II. Among the synthesized compounds, 5 k exhibited potent inhibition, with IC values of 89.25 nM and 54.
View Article and Find Full Text PDFClin Nucl Med
October 2025
Division of Nuclear Medicine, Department of Radiology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Purpose: To investigate whether the overall survival (OS) of patients with parkinsonism is associated with dopamine transporter activity in the striatum measured by 18 F-N-(3-fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane positron emission tomography ( 18 F-FP-CIT PET).
Methods: From March 2021 to December 2021, 18 F-FP-CIT PET images from patients with Parkinsonism were retrospectively reviewed. Dopamine transporter activity in each striatal region was automatically measured as striatal binding ratio (BR) from PET DICOM files using AI-based quantification (BTXBrain, v1.
Inorg Chem
July 2025
Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong.
We report herein three cyclometalated iridium(III) polypyridine complexes appended with a dendritic guanidinium unit [Ir(N^C)(bpy-Gu)](Cl) (bpy-Gu = 4-(-(3,4,5-tris(2-(2-(2-(4-((3,4,5-tris(2-(2-(2-guanidinoethoxy)ethoxy)ethoxy)benz-amido)methyl)-1-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)phenylcarbonyl)aminomethyl)-4'-methyl-2,2'-bipyridine; HN^C = 2-phenylpyridine (Hppy) (), 2-phenylquinoline (Hpq) (), and 2-(1-naphthyl)benzothiazole (Hbsn) ()) as molecular glues. Their guanidinium-free counterparts [Ir(N^C)(bpy-C4)](Cl) (bpy-C4 = 4-(-(-propylcarbonyl)aminomethyl)-4'-methyl-2,2'-bipyridine; HN^C = Hppy (), Hpq (), and Hbsn ()) were also isolated. Irradiation of the complexes led to intense greenish-yellow to red emission.
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