Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Myeloid sarcoma (MS) is an extramedullary myeloid tumor that sometimes presents with antedating systemic leukemia, leading physicians to the misdiagnosis of lymphoma. CD25 is expressed in 13% of patients with acute myeloid leukemia (AML), and its expression is associated with FLT3-ITD mutations, an elevated serum soluble interleukin 2 receptor (sIL-2R) level and a lower survival rate. However, there are no reports concerning the relationship between MS and the CD25 expression. We herein report a case of AML accompanied by thoracic epidural MS with a high CD25 expression, the FLT3-ITD mutation and an extremely elevated serum sIL-2R level in a 59-year-old man who presented with paraplegia.

Download full-text PDF

Source
http://dx.doi.org/10.2169/internalmedicine.53.1137DOI Listing

Publication Analysis

Top Keywords

cd25 expression
12
acute myeloid
8
myeloid leukemia
8
extramedullary myeloid
8
myeloid sarcoma
8
high cd25
8
expression flt3-itd
8
flt3-itd mutation
8
elevated serum
8
sil-2r level
8

Similar Publications

Background: Regulatory T cells (Tregs) are found to be critical for maintaining immune tolerance to self-antigens; however, their status in primary Sjögren's syndrome (pSS) remains unclear. We investigated alterations in the abundance of peripheral Tregs in a large pSS cohort and their implications for patients.

Methods: Levels of CD4+CD25+FOXP3+Treg cells in the peripheral blood of 624 patients with pSS, and 93 healthy controls (HCs) were detected using modified flow cytometry (FCM).

View Article and Find Full Text PDF

Background: Dysregulation of immune responses may influence the progression of metabolic dysfunction-associated steatotic liver disease (MASLD) to metabolic dysfunction-associated steatohepatitis (MASH). Our recent data suggest the role of Th17-related cytokines in fibrosis advancement in MASLD. Herein, we aimed to analyze T-regulatory and Th17-producing T-lymphocytes by flow cytometry with respect to MASLD progression.

View Article and Find Full Text PDF

Background: Stereotactic Ablative Radiotherapy (SABR) for early-stage non-small cell lung cancer (NSCLC) can stimulate an immune response against cancer. We evaluated changes in peripheral lymphocyte subpopulations and cytokines levels after SABR in patients with early-stage NSCLC. We examined how these changes relate to overall survival (OS) and disease-free survival (DFS).

View Article and Find Full Text PDF

Antagonizing Viral MicroRNAs Reduces Ocular HSV-1 Pathogenesis and Enhances Mucosal Immune Homeostasis.

Invest Ophthalmol Vis Sci

September 2025

Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois Chicago, Chicago, Illinois, United States.

Purpose: Herpes simplex virus 1 (HSV-1) is a globally prevalent pathogen that causes recurrent lesions at mucosal and cutaneous sites, including the cornea, leading to herpetic keratitis, a major cause of infectious blindness. While HSV-1-encoded microRNAs (v-miRs) are known to regulate viral latency and immune evasion, their role in acute mucosal infection remains unclear. This study investigates the function of v-miRs during acute HSV-1 infection of the cornea.

View Article and Find Full Text PDF

Sepsis, caused by an unbalanced host response to infection, remains a global health burden. The dysregulation between pro-inflammatory and anti-inflammatory responses is a primary driver of immune imbalance. As a central player in adaptive immunity, CD4 T cells are crucial for maintaining this balance during sepsis by differentiating into various effector T cell subsets.

View Article and Find Full Text PDF