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Reactive nitrogen (Nr) is an indispensable nutrient for agricultural production and human alimentation. Simultaneously, agriculture is the largest contributor to Nr pollution, causing severe damages to human health and ecosystem services. The trade-off between food availability and Nr pollution can be attenuated by several key mitigation options, including Nr efficiency improvements in crop and animal production systems, food waste reduction in households and lower consumption of Nr-intensive animal products. However, their quantitative mitigation potential remains unclear, especially under the added pressure of population growth and changes in food consumption. Here we show by model simulations, that under baseline conditions, Nr pollution in 2050 can be expected to rise to 102-156% of the 2010 value. Only under ambitious mitigation, does pollution possibly decrease to 36-76% of the 2010 value. Air, water and atmospheric Nr pollution go far beyond critical environmental thresholds without mitigation actions. Even under ambitious mitigation, the risk remains that thresholds are exceeded.
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http://dx.doi.org/10.1038/ncomms4858 | DOI Listing |
Mol Pharm
September 2025
Affiliated Hospital of Shandong Second Medical University, Shandong Second Medical University, Weifang 261053, Shandong, P. R. China.
Myocardial injury constitutes a life-threatening complication of sepsis, driven by synergistic oxidative-inflammatory pathology involving dysregulated production of reactive oxygen species (ROS), reactive nitrogen species (RNS), and proinflammatory cytokines. This pathophysiological cascade remarkably elevates morbidity and mortality rates in septic patients, emerging as a key contributor to poor clinical outcomes. Despite its clinical significance, no clinically validated therapeutics currently exist for managing septic cardiomyopathy.
View Article and Find Full Text PDFJ Phys Chem A
September 2025
Department of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York 14850, United States.
Ionic liquids (ILs) have been gaining increasing focus in a variety of applications including emerging electric-propulsion concepts. A quantitative understanding of how IL ions fragment during high-energy collisions with background gases is therefore essential for interpreting mass spectra, predicting ion lifetimes in plasma and vacuum environments, and designing IL-based technologies. This work uses molecular dynamics (MD) simulations with a reactive force field to numerically model the collision-induced dissociation (CID) of isolated ions (both positive and negative) and ion clusters (2:1 and 1:2 clusters) of the prototypical ionic liquid 1-ethyl-3-methylimidazolium tetrafluoroborate (EMIM-BF), colliding with a nitrogen (N) molecule, exploring all possible fragmentation channels arising from the breaking of both ionic and covalent bonds at collision energies ranging from 10 electron volts (eV) to 100 electron volts (eV) in the laboratory frame.
View Article and Find Full Text PDFOrg Lett
September 2025
College of Materials and Chemical Engineering, Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, China Three Gorges University, Yichang, Hubei 443002, P. R. China.
A novel copper-catalyzed radical cross-coupling reaction for the thioesterification of polyfluoroarenes is developed using KS and aldehydes in water. This protocol employs a readily available KS as a sulfur source, eliminating the need for hazardous thiols and organic solvents. The mild reaction conditions are compatible with a wide range of functional groups, providing access to diverse polyfluoroaryl thioesters.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
September 2025
Institute of Theoretical Chemistry, Faculty of Chemistry, University of Vienna, Währinger Str. 17, Vienna, 1090, Austria.
Density functional theory (DFT) is the standard approach for modeling MIL-101(Fe) and related Fe-based metal-organic frameworks, typically assuming a ferromagnetic high-spin configuration. However, this widely adopted approach overlooks a key electronic feature: Spin frustration in the triangular -O) nodes. Using flip-spin, broken-symmetry DFT, we identify the true ground state as an antiferromagnetic state that standard DFT fails to capture.
View Article and Find Full Text PDFJ Environ Manage
September 2025
College of chemistry and chemical Engineering, Ocean University of China, Qingdao, China. Electronic address:
Tidal estuaries serve as critical zones for biogeochemical connectivity between terrestrial and oceanic ecosystems. With climate change magnifying the impact of flood events on riverine system, dissolved organic matter (DOM) cycling, the largest reactive elemental pool in ecosystems, in tidal estuaries tend to be more complex and remain poorly understood. To address this gap, the response of DOM dynamics to flood events in a typical tidal estuary was explored.
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