Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Fragrance allergy is a lifelong condition that may give rise to permanent or recurrent contact dermatitis and may affect quality of life (QoL). The effect on QoL has not yet been investigated, and no disease-specific QoL instrument for fragrance allergy exists.
Objective: To develop and validate a disease-specific instrument to investigate QoL among fragrance-allergic subjects.
Method: A fragrance QoL instrument (FQL index) was developed on the basis of narratives from 68 fragrance-allergic subjects, and consisted of 13 items. It was tested in a postal survey among 1650 participants patch tested at Gentofte University Hospital (2000-2010). The survey included other QoL instruments [Dermatology Life Quality Index (DLQI) and Short Form 36 (SF36) version 2] and questions on eczema severity (response rate of 66%). A retest was conducted after 3-6 months (response rate of 72.5%).
Results: The FQL index showed a significant and strong correlation with the DLQI (r = 0.70), and disease severity, but a weak correlation with SF36 [mental component summary score, r = - 0.22; physical component summary score, r = - 0.31]. Good reliability and responsiveness to changes in disease severity were seen.
Conclusion: The FQL index is a good instrument with which to investigate QoL in subjects with fragrance allergy. Good correlations with the DLQI and self-estimated disease severity were seen, and it showed good reliability, reproducibility and ability to distinguish changes in disease severity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/cod.12153 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Potential Allergens in Medical Adhesives in Tapes, Wound Dressings, and Ostomy Care: A Scoping Review.
Contact Dermatitis
August 2025
Department of Dermatology, University Hospital Antwerp (UZA), and Research Group Immunology, University of Antwerp, Antwerp, Belgium.
Background: Medical adhesives are increasingly reported, although still underestimated as causes of allergic contact dermatitis, for which identification of the sensitising culprits is often impossible, mainly because of non-declaration of components on medical device packaging and lack of cooperation from manufacturers.
Objectives: To report on the allergens identified in medical adhesives in tapes, wound dressings, and ostomy care.
Methods: The relevant literature (1980-2024) on sensitization sources and allergens was analysed and the results reported.
Elucidating the Relationship Between Mycosis Fungoides and Contact Sensitization: A Retrospective Study.
Dermatitis
August 2025
School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Mycosis fungoides (MF), a type of cutaneous T cell lymphoma (CTCL), presents diagnostic challenges due to its complex etiology. Previous studies suggest a link between MF and type IV hypersensitivity, particularly allergic contact dermatitis (CD), but conclusive evidence is lacking. To investigate the relationship between MF and contact sensitization, focusing on positive patch test (PPT) results in a controlled, extensive study.
View Article and Find Full Text PDFA history of injury enhances affective and sensory responses to predator threat by sensitizing corticosterone release through TRPA1 receptor signaling.
Curr Biol
August 2025
Department of Psychology, University of Toronto Mississauga, Mississauga, ON L5L 1C6, Canada. Electronic address:
The ability to detect pain or other danger cues through experience and innate programs is a critical adaptive behavior. It enables organisms to recognize, learn, and remember threats, facilitating rapid and coordinated responses to imminent danger. In injured animals, pain sensitization enhances vigilance, allowing the animal to respond quickly to environmental threat cues.
View Article and Find Full Text PDFPopulation-level morphological analysis of paired CO- and odor-sensing olfactory neurons in via volume electron microscopy.
Elife
July 2025
Department of Neurobiology, University of California, San Diego, La Jolla, United States.
Dendritic morphology is a defining characteristic of neuronal subtypes. In , heterotypic olfactory receptor neurons (ORNs) expressing different receptors display diverse dendritic morphologies, but whether such diversity exists among homotypic ORNs remains unclear. Using serial block-face scanning electron microscopy on cryofixed tissues, we analyzed the majority of CO-sensing neurons (ab1C) and their odor-sensing neighbors (ab1D) in the antenna.
View Article and Find Full Text PDFOutcomes of the European baseline series patch test in the geriatric population.
Allergol Immunopathol (Madr)
July 2025
Division of Immunology and Allergy, Adana City Training and Research Hospital, Adana, Turkey.
Background: Skin aging causes various immunological and structural changes and increases the risk of many skin diseases such as contact dermatitis.
Objective: Our aim was to share the allergen contact dermatitis sensitivities of the elderly population with the European baseline series (EBS) results.
Materials And Methods: Patients aged 65 years and older who were patch tested with EBS in the immunology and allergy clinic between January 1, 2018, and March 1, 2025, were included in the study.