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Penile metastasis secondary to primary bladder cancer is a rare entity and represents a challenging problem. The common mode of spread to the penis is by retrograde venous route. The overall outcome is dismal and most patients will die within 1 year even after optimum treatment. Here, we report two such cases.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931244 | PMC |
http://dx.doi.org/10.4103/0973-1075.125565 | DOI Listing |
Urol Case Rep
November 2025
Department of Translational Medicine, University of Eastern Piedmont, Maggiore della Carità University Hospital, 28100, Novara, Italy.
The aim of this study is to report a case of penile metastasis from prostate carcinoma, as it represents a very rare occurrence that clinicians should be aware of. We report a case of a 68-year-old patient affected by prostate cancer who has performed a PSMA-PET after radical prostatectomy for PSA elevation, which revealed a suspected uptake in the corpora cavernosa and corpora spongiosum, followed by multiparametric MRI examination with focus on penile involvement.
View Article and Find Full Text PDFUrol Case Rep
September 2025
Edward Via College of Osteopathic Medicine, Louisiana Campus, 4408 Bon Aire Dr, Monroe, LA, 71203, United States.
Metastasis of a primary malignancy to the penis is rare with a limited number of reported cases this century. Of those cases, a small percentage are secondary to renal cell carcinoma, with most of these cases being caused by local invasion of prostate and bladder cancer. This report is that of a 70-year-old male who presented with penile swelling and pain, which was later determined to be secondary to metastatic renal cell carcinoma of the penis.
View Article and Find Full Text PDFMol Imaging Radionucl Ther
August 2025
Cobalt Medical Charity, Cheltenham, UK.
A 74-year-old man with a history of prostate cancer and rising prostate-specific antigen underwent F-prostate specific membrane antigen PSMA)-1007 positron emission tomography/computed tomography for investigation of oligometastatic disease. There was evidence of PSMA avid local recurrence findings with pelvic and retroperitoneal nodal metastases and skeletal deposits. Although rare and could easily be mistaken for contamination, a small penile metastasis was found.
View Article and Find Full Text PDFMedicine (Baltimore)
July 2025
Department of Urology, Nihon University School of Medicine, Tokyo, Japan.
Rationale: Penile metastasis from renal cell carcinoma (RCC) is an extremely rare clinical entity, particularly in the era of immune-checkpoint inhibitor and tyrosine-kinase inhibitor combination therapy. The mechanisms, clinical presentation, and optimal management of such cases remain poorly understood.
Patient Concerns: A 75-year-old man with metastatic RCC undergoing systemic therapy developed persistent, painful erections (malignant priapism), along with urinary retention, general malaise, and back pain, 2 years after initiating treatment.
Aktuelle Urol
July 2025
Institut für Pathologie, Universitätsklinikum Erlangen, Erlangen, Germany.
Penile carcinoma is a rare malignancy, predominantly derived from squamous epithelium, with a partially aggressive clinical course. The 2022 WHO classification distinguishes HPV-associated (HPV(+)) and HPV-independent (HPV(-)) subtypes, a differentiation that bears significant prognostic and therapeutic implications. HPV(-) carcinomas often develop as result of chronic inflammation, e.
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