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Background: Work-related stress is widely recognized as one of the major challenges to occupational health and safety. The correlation between work-related stress risk factors and physical health outcomes is widely acknowledged. This study investigated socio-demographic and occupational variables involved in perceived risk of work-related stress.
Methods: The Italian version of the Health and Safety Executive Management Standards Indicator Tool was used in a large survey to examine the relationship between work-related stress risks and workers' demographic and occupational characteristics. Out of 8,527 questionnaires distributed among workers (from 75 organizations) 6,378 were returned compiled (74.8%); a set of mixed effects models were adopted to test single and combined effects of the variables on work-related stress risk.
Results: Female workers reported lower scores on control and peer support and more negative perceptions of relationships and change at work than male workers, most of them with full-time contracts. Age, job seniority, and educational level appeared positively correlated with control at work, but negatively with job demands. Fixed-term workers had positive perceptions regarding job demands and relationships, but more difficulties about their role at work than permanent workers. A commuting time longer than one hour and shift work appeared to be associated with higher levels of risk factors for work-related stress (except for role), the latter having more negative effects, increasing with age.
Conclusions: The findings suggest that the assessment and management of work-related stress risk should consider specific socio-demographic and occupational risk factors such as gender, age, educational level, job status, shift work, commuting time, job contracts.
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http://dx.doi.org/10.1186/1471-2458-13-1157 | DOI Listing |
Clin Epigenetics
September 2025
Department of Psychiatry and Psychotherapy, Philipps University Marburg, Marburg, Germany.
Background: Work-related stress is a well-established contributor to mental health decline, particularly in the context of burnout, a state of prolonged exhaustion. Epigenetic clocks, which estimate biological age based on DNA methylation (DNAm) patterns, have been proposed as potential biomarkers of chronic stress and its impact on biological aging and health. However, their role in mediating the relationship between work-related stress, physiological stress markers, and burnout remains unclear.
View Article and Find Full Text PDFBMC Public Health
September 2025
Department of Sociology and Work Science, University of Gothenburg, Gothenburg, Sweden.
Background: Mental health problems are common in the working-age population. More knowledge is needed on how to support work participation and reduce sickness absence. The objective of the study was to estimate the distribution of mental well-being and work capacity in women and men in a working population and assess the association between mental well-being and work capacity, while adjusting for sociodemographic characteristics, health status, and working positions.
View Article and Find Full Text PDFMol Psychiatry
September 2025
Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, MA, USA.
Dysregulated dopaminergic signaling has been implicated in the pathophysiology of major depressive disorder (MDD) and childhood sexual abuse (CSA), but inconsistencies abound. In a multimodal PET-functional MRI study, harnessing the highly selective tracer [C]altropane, we investigated dopamine transporter availability (DAT) and resting-state functional connectivity (rsFC) within reward-related regions among 112 unmedicated individuals (MDD: n = 37, MDD/CSA: n = 18; CSA no MDD: n = 14; controls: n = 43). Striatal DAT and seed-based rsFC were assessed in the dorsal and ventral striatum and the ventral tegmental area.
View Article and Find Full Text PDFPlant Physiol Biochem
August 2025
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China. Electronic address:
The PR10 (Pathogenesis-Related Protein 10) family plays a crucial role in plant defense and growth regulation, with unique hydrophobic cavities that bind various ligands, including phytohormones and alkaloids. Among them, Norcoclaurine Synthases (NCS) are key enzymes in benzylisoquinoline alkaloid (BIAs) biosynthesis, catalyzing the Pictet-Spengler reaction to form the precursor (S)-norcoclaurine. However, the evolutionary origins and functions of the PR10 family in BIA biosynthesis remain unclear.
View Article and Find Full Text PDFJ Voice
September 2025
Department of Speech-Language-Hearing Sciences, Medical School, Federal University of Minas Gerais - UFMG, Belo Horizonte, Minas Gerais, Brazil. Electronic address:
Objective: To analyze the association between the risk of voice disorders and sociodemographic, work, and general health factors in urban and rural school teachers.
Methods: This is an observational, cross-sectional, analytical study with 1705 teachers from urban schools and 202 from rural schools teaching elementary and high school in Minas Gerais, Brazil. The exclusion criteria were being retired or no longer teaching and/or not accepting to participate in the study.