Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Polysaccharide nanoparticles are versatile functional materials used in drug delivery applications. Here we describe a method for the synthesis of β-1,3-glucan esters which show the formation of nanoparticles. Pyridine-soluble β-1,3-glucan formate was first synthesized as an intermediate and then reacted with various anhydrates to yield β-1,3-glucan acetate and hexaonate. The resultant esters were soluble in common organic solvents like acetone, pyridine and dimethylacetamide. By using a simple dialysis process, homogeneous hollow or solid nanospheres with diameter from 132 to 487 nm were prepared. The chemical structures of the obtained β-1,3-glucan esters were characterized and the morphologies of the β-1,3-glucan based nanoparticles were evaluated. These new types of nanoparticles could be potentially used for the encapsulation of hydrophobic drugs targeting immune cells.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.carbpol.2013.06.056 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Inhibiting Graphite Co-Intercalation through Weak Solvating Ether Electrolytes for Stable Cycling in Potassium-Ion Batteries.
J Phys Chem Lett
September 2025
Faculty of Material Science and Chemistry, China University of Geosciences, Wuhan 430074, China.
Ether-based electrolytes are widely acknowledged for their potential to form stable solid electrolyte interfaces (SEIs) for stable anode performance. However, conventional ether-based electrolytes have shown a tendency for cation-solvent co-intercalation phenomena on graphite electrodes, resulting in lower capacity and higher voltage platforms compared to those of neat cation insertion in ester-based electrolytes. In response, we propose the development of weakly solvating ether solvents to weaken the interaction between cations and solvents, thereby suppressing co-intercalation behavior.
View Article and Find Full Text PDFUnravelling the polysorbate 20 composition: A fusion of UPLC-MS analysis and stochastic modelling.
Eur J Pharm Biopharm
September 2025
RaDes GmbH, Schnackenburgallee 114, 22525 Hamburg, Germany. Electronic address:
Polysorbate 20 (PS20) is one of the most commonly used non-ionic surfactants in cosmetics, pharmaceuticals and food products. Considered as biocompatible and non-irritating, it is further valued for its solubilising and protein stabilising properties. PS20 is manufactured through a multi-stage reaction of sorbitol with various fatty acids and ethylene oxide, resulting in a complex mixture of components with different molecular weights and polarity.
View Article and Find Full Text PDFDetection of Anabolic Androgenic Steroids and Steroid Esters-Comparing Dried Blood Spots Collection Devices and Urine Samples.
Drug Test Anal
September 2025
Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.
Dried blood spots (DBS) have emerged as a promising complement, and in some settings, an alternative, to urine for anabolic androgenic steroid (AAS) testing, offering advantages such as minimal invasiveness, simplified storage, and transportation. This study evaluated two DBS collection devices-cellulose-based Capitainer-B50 and polymer-based Tasso-M20-and compared results with traditional urine analysis. Ten self-reported AAS users were recruited and provided matched urine and DBS samples.
View Article and Find Full Text PDFSweat-amplified dermal transfer and combined toxicity of per- and polyfluoroalkyl substances and organophosphate esters mixtures in children's textiles.
Sci Total Environ
September 2025
MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China. Electronic address:
The widespread application of chemical additives in textiles raises concerns about dermal exposure, especially in children. We analyzed 28 per- and polyfluoroalkyl substances (PFAS) and 9 organophosphate esters (OPEs) in household textiles and children's garments. PFAS were detected in 87.
View Article and Find Full Text PDFConfinement of highly dispersed bimetallic Nico nanoparticles in 3D hierarchically mesoporous zeolite with enhanced performance in biomass-derived vanillin hydrodeoxygenation.
J Colloid Interface Sci
September 2025
Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming 650093, China.
Encapsulation of non-noble bimetallic nanoparticles within a zeolite framework can improve the stability and accessibility of active sites, but the single microporous structure and poor metal stability decreased the catalytic performance of the catalyst. Here, 3D hierarchical ZSM-5 zeolite encapsulated NiCo nanoparticles (NiCo@3DHZ5) were synthesized by Bottom-up confined steam-assisted crystallization (SAC) one-pot hydrothermal method and applied to the hydrodeoxygenation of vanillin. A series of characterizations showed that highly stable alloyed NiCo nanoparticles were encapsulated in a framework of 3DHZ5, the strong metal-zeolite interactions resulted in highly dispersed NiCo nano-alloys facilitated hydrogen adsorption and spillover of active hydrogen atoms, and the 3D hierarchical structure promoted oxygenated substrate diffusion, the synergy interaction between the alloy particles confined in the 3DHZ5 pores and the acidic sites on the zeolite surface promoted the selective conversion of vanillin.
View Article and Find Full Text PDF