Comparative metabolomic analysis of an alternative biosynthetic pathway to pseudosugars in Actinosynnema mirum DSM 43827.

Chembiochem

Department of Pharmaceutical Sciences, Oregon State University, 203 Pharmacy Building, Corvallis, Oregon 97331 (USA).

Published: September 2013


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Article Abstract

Through a combination of genome mining, gene knockouts, and comparative metabolomic studies, a new biosynthetic pathway to validoxylamine A has been discovered in DSM 43827. The study revealed the rich diversity of biosynthetic pathways to pseudosugar-containing natural products.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835175PMC
http://dx.doi.org/10.1002/cbic.201300384DOI Listing

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