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Through a combination of genome mining, gene knockouts, and comparative metabolomic studies, a new biosynthetic pathway to validoxylamine A has been discovered in DSM 43827. The study revealed the rich diversity of biosynthetic pathways to pseudosugar-containing natural products.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835175 | PMC |
http://dx.doi.org/10.1002/cbic.201300384 | DOI Listing |
Front Genet
August 2025
Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, United States.
Introduction: Aging is accompanied by systemic metabolic changes that contribute to disease susceptibility and functional decline. Sex differences in aging have been reported in humans, yet their mechanistic basis remains poorly understood. Due to their physiological similarity to humans, rhesus macaques are a powerful translational model to investigate sex-specific metabolomic aging under controlled conditions.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
September 2025
State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University, Third Hospital, Beijing, China.
Objective: This study explores the metabolic profiles in the peripheral blood of infertile patients with adenomyosis (ADM) to identify key metabolites affecting pregnancy outcomes in these patients undergoing frozen embryo transfer (FET). Our goal is to create a metabolite-based clinical prediction model for pregnancy outcomes in adenomyosis-associated infertility.
Methods: This prospective cohort study from the Reproductive Center at Peking University Third Hospital enrolled 94 infertile patients with adenomyosis and control (CTRL) patients undergoing FET.
Plant Physiol Biochem
September 2025
Shanxi Normal University, Taiyuan, 030000, PR China.
Suaeda salsa(S.salsa) is a promising halophytic species for vegetation restoration in highly saline-alkali soils. Carboxylated single-walled carbon nanotubes (COOH-SWCNTs) have emerged as potential agents for modulating plant responses to abiotic stress.
View Article and Find Full Text PDFEcotoxicol Environ Saf
September 2025
Chongqing Ecological and Environmental Monitoring Center, Chongqing 401147, PR China. Electronic address:
Plastics degradation generates microplastics (MPs), posing a risk to soil function and organisms. Currently, the impact of MPs derived from different polymers remains poorly understood. In this study, the effects of three polymers (polypropylene (PP), polylactic acid (PLA), and polybutylene adipate terephthalate (PBAT)) were investigated at environmentally relevant levels (0, 0.
View Article and Find Full Text PDFRes Vet Sci
September 2025
Interdisciplinary Laboratory of Clinical Pathology, Interlab-UMU, Campus of Excellence Mare Nostrum, University of Murcia, 30100 Murcia, Spain. Electronic address:
Recent years have seen advances in clinical biochemistry of domestic animals which have highlighted comparative differences between species and have also identified fundamental aspects of the biochemical mechanisms in physiological conditions and disease, that have implications across species, including human, health and welfare. From investigations in diverse species using biochemical, immunological, proteomic and metabolomic approaches a series of species particularities and unexpected results for some biomarkers have been made. These observations cover (1) the differences between species in the acute phase protein (APP) response to infection and inflammation; (2) the non-hepatic synthesis and release in the mammary gland, adipose tissue and intestine of APP (3) the response of haptoglobin (HP) as a biomarker for stress; (4) observations in non-mammalian species related to hemopexin and HP; (5) the response of bile acids in milk to mastitis; (6) barley serine protease inhibitors being identified in bovine faeces; (7) alkaline phosphatase being present in bovine nasal secretion; (8) saliva findings with analytes such as adenine deaminase showing different activity between saliva and serum and a detergent-like surfactant protein, latherin being found in equine saliva and sweat and (9) serum enzymes and selective muscle protein reaction of Atlantic salmon as an example of the differences in biochemistry between terrestrial and aquatic species.
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