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Multiple research groups are currently attempting to develop less-invasive robotic capsule endoscopes (RCEs) with better outcomes for enteroscopic procedures. Understanding the biomechanical response of the bowel to RCE is crucial for optimizing the design of these devices. For this reason, this study aims to develop an analytical model to predict the anchoring force of the model when travelling through the intestine. Previous work has developed, characterized and tested the frictional characteristics of the intestine with microgroove structures that had different surface contours. This work tested basic anchoring force characteristics with custom-built testers and clamping mechanism dummies to analyse the robot clamping movement (which is vital to improving movement efficiency). Balloon-shaped and leg-based clamping mechanisms were developed, which were found to have variable anchoring forces from 0.01 N to 1.2 N. After analysing the experimental results it was found that: (a) robot weight does not play a major role in anchoring force; (b) an increase in anchoring force corresponded to an increase in diameter of the clamping mechanism; and (c) textured contact surfaces effectively increased friction. These results could be explained by the biomechanical response of the intestine, friction and mucoadhesion characteristics of the small intestine material. With these factors considered, a model was developed for determining anchoring force in the small intestine.
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http://dx.doi.org/10.3109/03091902.2013.812688 | DOI Listing |
PLoS One
September 2025
School of Civil Engineering, Shandong Jianzhu University, Jinan, China.
In engineering structure performance monitoring, capturing real-time on-site data and conducting precise analysis are critical for assessing structural condition and safety. However, equipment instability and complex on-site environments often lead to data anomalies and gaps, hindering accurate performance evaluation. This study, conducted within a wind farm reinforcement project in Shandong Province, addresses these challenges by focusing on anomaly detection and data imputation for weld nail strain, anchor cable axial force, and concrete strain.
View Article and Find Full Text PDFDesmosomes (DSMs) are intercellular junctions essential for providing mechanical resilience to tissues, particularly the epidermis. Desmoplakin (DP) is a key DSM protein which anchors plaque proteins to keratins, thereby ensuring tissue integrity under mechanical stress. Clinically, DP mutations impair keratinocyte adhesion and structural integrity, leading to skin fragility disorders.
View Article and Find Full Text PDFUnlabelled: Plasma membrane (PM) lipids and proteins are organized into nanoscale regions called nanodomains, which regulate essential cellular processes by controlling local membrane organization. Despite advances in super-resolution microscopy and single particle tracking, the small size and temporal instability of nanodomains make them difficult to study in living cells. To overcome these challenges, we built fluorescent DNA origami probes that insert into the PM via lipid anchors displayed on the cell.
View Article and Find Full Text PDFJ Biomol Struct Dyn
September 2025
Medical College, Hebei University of Engineering, Handan, China.
N-terminal glycine (Gly/N-degron), as a degradation signal, can be recognized by specific E3 ubiquitin ligases and plays a crucial role in protein degradation and cellular homeostasis. As a substrate receptor in the Cullin 2-RING E3 ligase complex, ZER1 mediates protein degradation the Gly/N-degron pathway by recognizing N-terminal glycine and other small residues. This study employed all-atom molecular dynamics (MD) simulations and binding free energy calculations to explore ZER1's recognition of the wild-type peptide GFLHVGQD (WT) and its N-terminal mutants (G1S, G1A, G1T, and G1C).
View Article and Find Full Text PDFActa Biomater
August 2025
Shanghai Frontiers Science Center of Advanced Textiles, College of Textiles, Donghua University, Shanghai 201620, China; Key Laboratory of Textile Science &Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China; Key Laboratory of Textile Industry for Biome
Microneedle patches can penetrate the myocardium to facilitate integration with cardiac tissue, offering a promising approach for myocardial infarction (MI) repair. However, their clinical translation has been hindered by insufficient fixation stability during cardiac contractions and mismatch with myocardial anisotropy. To address these challenges, a bioinspired three-dimensional cardiac patch integrating barbed microneedles and an anisotropic lightweight mesh was designed.
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