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Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biological activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides.
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http://dx.doi.org/10.1016/j.bmcl.2013.03.031 | DOI Listing |
J Agric Food Chem
September 2025
School of Pharmaceutical Sciences Guizhou University, Guiyang 550025 P. R. China.
Insecticide misuse has caused pest resistance, stressing the need for novel pesticides. The isoxazoline structure offers broad-spectrum effectiveness, mammalian safety, and no cross-resistance. Developing efficient insecticides with this scaffold remains challenging.
View Article and Find Full Text PDFExp Appl Acarol
August 2025
Department of Plant Protection, Faculty of Agriculture, Ankara University, 06135, Ankara, Türkiye.
Tetranychus urticae Koch (Acari: Tetranychidae) is a widespread pest that causes significant crop losses. Although acaricides are commonly used for its control, the development of resistance often leads to control failures under field conditions. Therefore, there is a constant need for new compounds with novel modes of action.
View Article and Find Full Text PDFVet Parasitol Reg Stud Reports
August 2025
Boehringer Ingelheim Animal Health, 29 Avenue Tony Garnier, 69007 Lyon, France.
Heterodoxus spiniger is a chewing louse of a diverse range of hosts, primarily Carnivora. Domestic dogs are considered a major host, and infestations can lead to pruritus, hair loss, or seborrhea. In the context of absence of clinical trials evaluating the efficacy of isoxazolines against H.
View Article and Find Full Text PDFCan Vet J
August 2025
St. Vital Veterinary Hospital, Winnipeg, Manitoba (Ziaieardestani, Kolebaba, Hauck); Department of Animal Science, Faculty of Agriculture and Food Sciences, University of Manitoba, Winnipeg, Manitoba (Naserli).
Feline demodicosis is a rare parasitic skin disease. The clinical signs, which may range from mild and localized to severe and generalized, include alopecia, erythema, macules, pruritus, and hyperpigmentation. Although many studies have evaluated the safety and efficacy of different miticidal agents for canine demodicosis, there have been no controlled or conclusive studies on feline infection.
View Article and Find Full Text PDFJ Agric Food Chem
August 2025
State Key Laboratory of Elemento-Organic Chemistry, Department of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, China.
The current economic globalization is inextricably linked to the process of agricultural globalization, and the development of efficient and green pesticides is particularly crucial to this process. In this work, a series of isoxazoline derivatives targeting the -aminobutyric acid (GABA) receptors of lepidopteran insects were designed, utilizing the CoMFA model to guide the splicing of bioactive fragments. Subsequently, these novel compounds were synthesized, characterized, and evaluated.
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