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The space-time permutation scan statistic (STPSS) is designed to identify hot (and cool) spots of space-time interaction within patterns of spatio-temporal events. While the method has been adopted widely in practice, there has been little consideration of the effect inaccurate and/or incomplete input data may have on its results. Given the pervasiveness of inaccuracy, uncertainty and incompleteness within spatio-temporal datasets and the popularity of the method, this issue warrants further investigation. Here, a series of simulation experiments using both synthetic and real-world data are carried out to better understand how deficiencies in the spatial and temporal accuracy as well as the completeness of the input data may affect results of the STPSS. The findings, while specific to the parameters employed here, reveal a surprising robustness of the method's results in the face of these deficiencies. As expected, the experiments illustrate that greater degradation of input data quality leads to greater variability in the results. Additionally, they show that weaker signals of space-time interaction are those most affected by the introduced deficiencies. However, in stark contrast to previous investigations into the impact of these input data problems on global tests of space-time interaction, this local metric is revealed to be only minimally affected by the degree of inaccuracy and incompleteness introduced in these experiments.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567134 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052034 | PLOS |
BMC Health Serv Res
September 2025
African Population and Health Research Center (APHRC), APHRC Campus, 2nd Floor, Manga Close off Kirawa Road, P.O. Box 10787-00100, Nairobi, Kenya.
Background: Maternal healthcare (MHC) in Cameroon reflects the persistent challenges in Sub-Saharan Africa, where high maternal mortality continues despite improved service utilization, stressing inequitable effective coverage (EC). This study applied EC cascade analysis-including service contact, continuity, and input-adjusted coverage-to quantify geographic and socioeconomic disparities, informing equity-focused strategies to dismantle structural barriers in the MHC continuum.
Methods: We combined population and health facility data (2018 Cameroon Demographic and Health Survey and 2015 Emergency Obstetric and Neonatal Care Assessment) to estimate the input-adjusted coverage of antenatal care (ANC) and intra-and postpartum care (IPC).
Metabolomics
September 2025
Toxalim (Research Centre in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
Introduction: Initially developed for transcriptomics data, pathway analysis (PA) methods can introduce biases when applied to metabolomics data, especially if input parameters are not chosen with care. This is particularly true for exometabolomics data, where there can be many metabolic steps between the measured exported metabolites in the profile and internal disruptions in the organism. However, evaluating PA methods experimentally is practically impossible when the sample's "true" metabolic disruption is unknown.
View Article and Find Full Text PDFDiabet Med
September 2025
Endocrinology Department, East Surrey Hospital, Surrey and Sussex Healthcare NHS Trust, Redhill, UK.
Aim: To explore the experiences of patients, families and clinicians managing steroid-induced hyperglycaemia (SIH) out of the hospital and identify areas for improved care.
Methods: We searched hospital records to identify patients requiring input from the diabetes inpatient team between February 2022 and March 2023 due to steroid usage. Clinicians, patients and their family members were interviewed remotely about their experiences of care and views on how to improve it.
AJNR Am J Neuroradiol
September 2025
From the Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America (J.S.S., B.M., S.H., A.H., J.S.), and Department of Aerospace Engineering, Indian Institute of Technology Madras, Chennai, Tamil Nadu, India (H.S.).
Background And Purpose: The choroid of the eye is a rare site for metastatic tumor spread, and as small lesions on the periphery of brain MRI studies, these choroidal metastases are often missed. To improve their detection, we aimed to use artificial intelligence to distinguish between brain MRI scans containing normal orbits and choroidal metastases.
Materials And Methods: We present a novel hierarchical deep learning framework for sequential cropping and classification on brain MRI images to detect choroidal metastases.
J Neurosci
September 2025
Institute of Psychology, Leiden University, the Netherlands.
Although phasic alertness generally benefits cognitive performance, it often increases the impact of distracting information, resulting in impaired decision-making and cognitive control. However, it is unclear why phasic alertness has these negative effects. Here, we present a novel, biologically-informed account, according to which phasic alertness generates a transient, evidence-independent input to the decision process.
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