Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681479PMC
http://dx.doi.org/10.18632/oncotarget.771DOI Listing

Publication Analysis

Top Keywords

promise dual
4
dual targeting
4
targeting akt/mtor
4
akt/mtor signaling
4
signaling lethal
4
lethal prostate
4
prostate cancer
4
promise
1
targeting
1
akt/mtor
1

Similar Publications

Hypocretin: a promising target for the regulation of homeostasis.

Front Neurosci

August 2025

Beijing Life Science Academy, Beijing, China.

Hypocretin, also known as orexin, is a hypothalamic neuropeptide that regulates essential physiological processes including arousal, energy metabolism, feeding behavior, and emotional states. Through widespread projections and two G-protein-coupled receptors-HCRT-1R and HCRT-2R-the hypocretin system exerts diverse modulatory effects across the central nervous system. The role of hypocretin in maintaining wakefulness is well established, particularly in narcolepsy type 1 (NT1), where loss of hypocretin neurons leads to excessive daytime sleepiness and cataplexy.

View Article and Find Full Text PDF

Target the Heart: A New Axis of Alzheimer's Disease Prevention.

J Dement Alzheimers Dis

June 2025

Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA.

Background/objective: Cyclosporine A and other calcineurin inhibitors have been identified as prospective treatments for preventing Alzheimer's disease. We previously found that calcineurin inhibitors elicit a unique behavioral profile in zebrafish larvae, characterized by increased activity, acoustic hyperexcitability, and reduced visually guided behaviors. Screening a large library of FDA-approved compounds using Z-LaP Tracker revealed that some heart medications produce a similar behavioral profile, suggesting these drugs may exert calcineurin-inhibitor-like effects relevant to prevent-ing or ameliorating Alzheimer's disease.

View Article and Find Full Text PDF

Background And Aim: The global shift toward antibiotic-free poultry production necessitates sustainable alternatives to conventional growth promoters. Hydrolyzable tannins (HTs) from plants have shown antimicrobial, antioxidant, and gut-modulatory effects, making them promising feed additives. However, reliance on imported tannins from temperate species limits access for tropical producers, especially in Thailand.

View Article and Find Full Text PDF

Exploring the effect of copper on the bioactivity of 8-quinolines: an and study.

Dalton Trans

September 2025

Biomedical Inorganic Chemistry Lab, Department of Chemical Sciences, University of Catania, v.le A. Doria 6, 95125, Catania, Italy.

Current anticancer therapy is challenged by the adaptability and resistance of tumor cells as well as limited drug selectivity that causes severe side effects. The scientific community maintains high interest in metal-based chemotherapeutic agents due to their unique interactions with cancer cells, potentially overcoming resistance mechanisms and exploiting the physiopathology of the tumour tissues. Copper, in particular, plays a dual role in cancer, both facilitating tumor progression and triggering cuproptosis, a copper-induced cell death mechanism.

View Article and Find Full Text PDF

Single-Molecule Dual-Anchor Design Enables Extreme-Condition Lithium Metal Batteries Through Solvation Reconstruction and Cathode Polymerization.

Angew Chem Int Ed Engl

September 2025

State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Electrochemical Process and Technology of Materials, Beijing University of Chemical Technology, Beijing, 10029, P.R. China.

Lithium metal batteries (LMBs) have emerged as the most promising candidate for next-generation high-energy-density energy storage systems. However, their practical implementation is hindered by the inability of conventional carbonate electrolytes to simultaneously stabilize the lithium metal anode and LiNiCoMnO (NCM811) cathode interfaces, particularly under extreme operating conditions. Herein, we present a transformative molecular design using 3,5-difluorophenylboronic acid neopentyl glycol ester (DNE), which uniquely integrates dual interfacial stabilization mechanisms in a single molecule.

View Article and Find Full Text PDF