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Introduction: Excessive fluid intake can lead to water intoxication, electrolyte abnormalities, exacerbation of heart failure and anatomical changes in the urinary tract that may present diagnostic and therapeutic challenges for patients and physicians. Although the development of nonobstructive hydronephrosis is recognized in patients with central and nephrogenic diabetes insipidus, pregnancy or psychiatric polydipsia, it is rarely a diagnostic consideration in healthy individuals with excessive fluid ingestion. We now present what we believe to be the first report of nonobstructive hydronephrosis associated with social polydipsia.
Case Presentation: A 53-year-old African-American woman with moderate back pain was found to have bilateral moderate hydronephrosis and hydroureter by abdominal computed tomography. She underwent ureteral stent placement followed by exploratory laparoscopy with lysis of adhesions and a right oophorectomy, without resolution of the nonobstructive hydronephrosis. A careful assessment revealed a social habit of consuming approximately 5.5L of fluid daily in an effort to remain hydrated in accordance with public health service announcements. It was recommended that the patient reduce her fluid intake. A repeat ultrasound after six weeks revealed complete resolution of the bilateral hydronephrosis and hydroureter.
Conclusion: Recognition of the nonobstructive nature of hydronephrosis caused by polydipsia in healthy individuals is important to prevent unnecessary interventions.
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http://dx.doi.org/10.1186/1752-1947-6-376 | DOI Listing |
BMC Med Imaging
August 2025
Department of Radiology and Nuclear Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Background: Hydronephrosis is a common finding on renal ultrasound, but its physiological causes-such as hydration-induced distention-remain under-recognized in healthy individuals. Misinterpreting such cases as pathological may lead to unnecessary investigations. This study aimed to determine whether rapid oral hydration induces transient hydronephrosis in healthy adults, and to characterize its timing, laterality, and reversibility.
View Article and Find Full Text PDFInt Urol Nephrol
August 2025
Department of Pediatrics, VMMC & Safdarjung Hospital, New Delhi, India.
Background: Crossed fused ectopia (CFE) and horseshoe kidney (HSK) are the fusion anomalies of the kidney. Due to paucity of data on these disorders from India, we assessed the clinico-radiological profile and outcomes of these children.
Materials And Methods: Clinical records of radiologically confirmed cases of CFE and HSK, attending the Pediatric nephrology clinic at a tertiary care center were reviewed retrospectively.
Sci Rep
July 2025
Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok, 10400, Thailand.
Abnormal fluid accumulation in the renal pelvis and calyces, with enlargement of the pelvicalyceal system, leads to a devastating disease known as hydronephrosis, which subsequently induces progressive renal impairment and mineral imbalance. Since the renal tubular cells play a role in the conversion of 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D [1,25(OH)D], an important calciotropic hormone, we hypothesized that the ICR/Mlac-hydro mice with bilateral non-obstructive hydronephrosis and hypoparathyroidism plausibly manifested derangements of calcium and bone metabolism. The results showed that Mlac-hydro mice had reductions in the levels of intact parathyroid hormone, 1,25(OH)D and fibroblast growth factor-23, along with downregulated TRPV6 expression in the duodenum and ~ 50% reduction in calcium flux as determined by Ca radioactive tracer.
View Article and Find Full Text PDFJ Pediatr Surg
June 2025
Department of Pediatric Surgery and Pediatric Urology, University Children's Hospital Tuebingen, Tuebingen, Germany.
Background: Megacalycosis is a rare non-obstructive congenital anomaly of the kidneys. The underlying pathogenesis has not yet been understood. Theories include the coexistence of distinct calyceal developmental stages, malformation of the calyceal structure, and transient, self-limiting obstruction.
View Article and Find Full Text PDFJ Pediatr Surg
August 2025
Department of Paediatric Urology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India. Electronic address:
Background: While the role of urinary biomarkers in differentiating non-obstructive dilatation (NOD) from ureteropelvic junction obstruction (UPJO) has been documented, there are limited reports on their utility in post-operative follow-up. This study aimed to document the values of urinary biomarkers: carbohydrate antigen (CA 19-9), neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule (KIM-1) following pyeloplasty.
Methods: In this prospective study, children with UPJO (those who worsened on ultrasound, or on renogram, or became symptomatic underwent dismembered pyeloplasty).