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Aim: To investigate the prevalence rate of hepatitis B (HVB) and hepatitis C (HCV) co-infection in HIV positives in Mazandaran province.
Methods: This descriptive cross-sectional study lasted from 2008 to 2010. The population of this study included 188 HIV positive persons confirmed to be infected by tests of ELISA I, II and western blood (WB) in the hospitals of Mazandaran University of Medical Sciences and Health Services. After getting permission, 5 cc venous blood samples were taken and drawn into a lab tube without citrate.
Results: Among the total of 188 HIV positive patients in Mazandaran province, only 80 patients were available, 62 had moved to other provinces, and 46 had died. Of the samples, 66 (82.5%) were males and 14 (17.5%) were females with the mean age of 37. Among the patients, nine (11.3%) were co-infected with HIV/ HBV, 27(33.8%) with HIV/HCV, while 20 (25%) were co-infected with HIV/HBV/ HCV. Only one patient had travelled abroad and eight of them stated that they had used shared syringes.
Conclusion: The differences in the rate of HBV and HCV co-infection can be due to the epidemiologic conditions of viruses with different factors including different risk factors causing infection with these factors such as the rate of virus penetrating the body, the manner of penetration, patients' health condition, patients' culture, and their socio-economic condition, etc.
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mBio
September 2025
Fred Hutchinson Cancer Center, Vaccine and Infectious Disease Division, Seattle, Washington, USA.
Accurate timing estimates of when participants acquire HIV in HIV prevention trials are necessary for determining antibody levels at acquisition. The Antibody-Mediated Prevention (AMP) Studies showed that a passively administered broadly neutralizing antibody can prevent the acquisition of HIV from a neutralization-sensitive virus. We developed a pipeline for estimating the date of detectable HIV acquisition (DDA) in AMP Study participants using diagnostic and viral sequence data.
View Article and Find Full Text PDFJ Viral Hepat
October 2025
Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Discontinuing antivirals in chronic hepatitis B virus (HBV) 'e' antigen negative infection can enhance HBV surface antigen (HBsAg) loss but risks complications. We modelled the clinical impact of discontinuing antivirals in chronic HBV. We developed a Markov state model with Monte Carlo simulation of chronic HBV to compare continuation of antiviral therapy with 3 strategies of cessation and reinitiation for: (1) virologic relapse, (2) clinical relapse, or (3) hepatitis flare.
View Article and Find Full Text PDFGeospat Health
July 2025
Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing.
Investigating the spatial effects of population mobility on Human Immunodeficiency Virus (HIV) epidemics provides valuable insights for effective disease control. Data on the incidence and prevalence of HIV and socioeconomic factors from 2013 to 2022 across 31 provinces in China were collected. The Baidu migration index was employed to construct inter-provincial population migration matrices for spatial lag models to evaluate spatial spill-overs and influx risks associated with HIV epidemics macroscopically.
View Article and Find Full Text PDFKaposi sarcoma (KS) is an angioproliferative malignancy associated with human herpesvirus 8 (HHV-8) infection, predominantly affecting immunocompromised patients such as those with HIV/AIDS. Despite advances in antiretroviral therapy, KS remains a significant cause of morbidity and mortality in this population, especially when diagnosis or treatment is delayed. Ocular involvement, although rare, can lead to significant functional impairment.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of Orthopaedics, Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing, China.
Osteoporosis is a common metabolic bone disease characterized by decreased bone density and increased fracture risk. Human immunodeficiency virus (HIV) infection is considered one of the independent risk factors for osteoporosis, but its specific mechanisms are not yet clear. This study aims to explore the relationship between HIV infection and osteoporosis based on the National Health and Nutrition Examination Survey database and to analyze the impact of related clinical factors on bone density.
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